Q8ZYK4
Gene name |
rfcS1 |
Protein name |
Replication factor C small subunit 1 |
Names |
RFC small subunit 1, Clamp loader small subunit 1 |
Species |
Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2) |
KEGG Pathway |
pai:PAE0734 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8ZYK4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8ZYK4-F1 | Predicted | AlphaFoldDB |
No variants for Q8ZYK4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q8ZYK4 | |||||
No associated diseases with Q8ZYK4
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| DNA replication factor C complex | A complex that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase. In eukaryotes the complex consists of five polypeptides. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| DNA clamp loader activity | Facilitating the opening of the ring structure of the PCNA complex, or any of the related sliding clamp complexes, and their closing around the DNA duplex, driven by ATP hydrolysis. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA repair | The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. |
| DNA-templated DNA replication | A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAELFWFEKY | RPRSFDEVVD | LEEVKARLRE | FVKAGNMPHL | LFYGPPGTGK | TTMALVLARE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LYGEYWRENT | LELNASDERG | INVIRERVKE | FARTAPVGKA | PFKLVILDEA | DNMTSDAQQA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LRRIMEIYAQ | NTRFILLANY | VSRIIDPIIS | RCAVFRFSPM | PRSLMAERLK | FIAKNEGVEL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| REDAINMIYE | LSEGDMRKAI | NLLQVAAATN | KVVDANAVAS | AAIAVRPADI | IELFNLAISG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DFVKAREKLR | ELMYLKGIAG | ADFIRAFQRE | LIRMPIDDDI | KAEIAELLAD | VDYRLTQGAD |
| 310 | 320 | ||||
| EEIQLTYLLT | KLGAIGRRVK | PATTQPRKK |