Q8ZYH2
Gene name |
tgtA |
Protein name |
tRNA-guanine(15) transglycosylase |
Names |
7-cyano-7-deazaguanine tRNA-ribosyltransferase, Archaeal tRNA-guanine transglycosylase |
Species |
Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2) |
KEGG Pathway |
pai:PAE0777 |
EC number |
2.4.2.48: Pentosyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8ZYH2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8ZYH2-F1 | Predicted | AlphaFoldDB |
No variants for Q8ZYH2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q8ZYH2 | |||||
No associated diseases with Q8ZYH2
1 regional properties for Q8ZYH2
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | tRNA-guanine(15) transglycosylase-like | 3 - 334 | IPR002616 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.4.2.48 | Pentosyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| metal ion binding | Binding to a metal ion. |
| pentosyltransferase activity | Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor). |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| queuosine biosynthetic process | The chemical reactions and pathways resulting in the formation of queuosines, a series of nucleosides found in tRNA and having an additional pentenyl ring added via an NH group to the methyl group of 7-methylguanosine. The pentenyl ring may carry other substituents. |
| tRNA wobble guanine modification | The process in which a guanine in t position 34 of a tRNA is post-transcriptionally modified. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSFEIIAKDL | AGRVGKLYTK | SGVIETPALF | PVVDPRKQEL | PSAVIERYFG | QIITNAYFVY |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RLTGGRAVDI | KKVLSWNAVL | MTDSGAYQIL | RYGSVEVDPD | EILQFQARIG | SDIGVILDLP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FDYEEPYESA | LLKVEETIRR | AKRASAMLDK | LEDMLVVGPI | QGGLYLDLLA | TSAREISKLG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FHIFAVGSPT | TLLEEYRFDL | LLEVILHVKA | NILREAPLHL | FGAGHPLVLP | FAVALGVDLF |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DSASYILYAR | DDRIMLRDRT | LRLEDVKTDY | LPCSTKLCHK | PVKELREMPH | EERIQLIAEH |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NLAILREELL | EIKQRIHEGT | LWEYLEIKAR | AHPTLYRFLR | SLGRYKRLIE | EYDPETHPET |
| 370 | 380 | 390 | 400 | 410 | 420 |
| HGLFFYQDTA | ESRPEPHRHW | SRTANLYTPS | KVAIVIRAGE | KPYNKSWEYR | YLKSLVGDRA |
| 430 | 440 | 450 | 460 | 470 | 480 |
| HVLFYDPVFG | LVPEEVAEIY | PLSQNEAEGE | SEAARAFAYE | WLNNYDVILL | YRVDLPMLSK |
| 490 | |||||
| KVIPLRSLDD | VLHYI |