Q8ZW77

PR
Gene name
tyrS2
Protein name
Tyrosine--tRNA ligase 2
Names
Tyrosyl-tRNA synthetase 2, TyrRS 2
Species
Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2)
KEGG Pathway
pai:PAE1931
EC number
6.1.1.1: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

168-251 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8ZW77

Entry ID Method Resolution Chain Position Source
AF-Q8ZW77-F1 Predicted AlphaFoldDB

No variants for Q8ZW77

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8ZW77

No associated diseases with Q8ZW77

3 regional properties for Q8ZW77

Type Name Position InterPro Accession
domain Tubulin/FtsZ, GTPase domain 3 - 246 IPR003008
conserved_site Tubulin, conserved site 142 - 148 IPR017975
domain Tubulin/FtsZ, 2-layer sandwich domain 248 - 393 IPR018316

Functions

Description
EC Number 6.1.1.1 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tyrosine-tRNA ligase activity Catalysis of the reaction: L-tyrosine + ATP + tRNA(Tyr) = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + 2 H(+).

1 GO annotations of biological process

Name Definition
tyrosyl-tRNA aminoacylation The process of coupling tyrosine to tyrosyl-tRNA, catalyzed by tyrosyl-tRNA synthetase. The tyrosyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a tyrosine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MERLLMNVEE VVTREEFLRL KGGSAYLGFE PLWPIHIGWL IWAYKLAELK EAGFDVIVLV
70 80 90 100 110 120
ATWHAWINDK GSIEELRAHG ERVRAVLDRI GKFKYVYGDD VAKDPKYWEL VVKIAKETSL
130 140 150 160 170 180
ARVKRATPVM GRRAEEVELD FSKLMYPLMQ VADIFYLGVD VAVGGMDQRR AHMLARDVAE
190 200 210 220 230 240
KLGLKKPIAL HTPIITSLSG TGRMEGTHRE IDEVYAMYKM SKSKPQSAIL ITDSEEDVRK
250 260 270 280 290 300
KIWAAYCPPR ETKFNPVFEI AAYLLIPYHG PLEIKGRRYE EGNALERDYR EGVVTPQELK
310
EAVASALVGL LSKLKL