Q8ZVG2

PR
Gene name
valS (PAE2297)
Protein name
Valine--tRNA ligase
Names
Valyl-tRNA synthetase, ValRS
Species
Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2)
KEGG Pathway
pai:PAE2297
EC number
6.1.1.9: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

570-639 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8ZVG2

Entry ID Method Resolution Chain Position Source
AF-Q8ZVG2-F1 Predicted AlphaFoldDB

No variants for Q8ZVG2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8ZVG2

No associated diseases with Q8ZVG2

3 regional properties for Q8ZVG2

Type Name Position InterPro Accession
domain Aminoacyl-tRNA synthetase, class Ia 17 - 564 IPR002300
domain Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding 610 - 757 IPR013155
domain Valyl tRNA synthetase, anticodon-binding domain 572 - 703 IPR033705

Functions

Description
EC Number 6.1.1.9 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

3 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
valine-tRNA ligase activity Catalysis of the reaction: L-valine + ATP + tRNA(Val) = L-valyl-tRNA(Val) + AMP + diphosphate + 2 H(+).

1 GO annotations of biological process

Name Definition
valyl-tRNA aminoacylation The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. The valyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a valine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAHRLPTRWD IKWEEELLKL WEKEGRFKTK ISGSRPVFVI DTPPPYLSSN RPHIGQTASY
70 80 90 100 110 120
AHFDMIARFL RMRGVDVIFP FYLDRNGLPI EVQVEKKYGV VAHEIPREKF IKMCKEELDS
130 140 150 160 170 180
YEGEFVSSLR RWGLSFDYWP NGTDSPEYRR MTQKTFIELW HKGLVYEAER PTPWCPRCRT
190 200 210 220 230 240
ALAEPEIEYR EEETYLNYIK FKVKETGEDI IIATTRPELL PATVAVIFHP DDSRYTRLNG
250 260 270 280 290 300
MHAVVPPEGQ VVPILPHKAA NPNFGSGLVM ISTFGDTRDL MIVNELKLPI RIIIDEGGRI
310 320 330 340 350 360
KTGKYAGVSI REARAKIIED LKNAGLLVKQ ERLVHNVPVC WRCKTPLEII VTRELFIKQI
370 380 390 400 410 420
EFKEKLIELA GKMEFKPPEY RQVLIDWIKS LELDWPVSRR RYYATEIPIW WCAKPNGERV
430 440 450 460 470 480
PLLPKGGEYY VPWRDEPPPE VKEACKDGRL EGDTRVFDTW FDSSISWMYA SGVTKDFNAF
490 500 510 520 530 540
SKVYPHSIMR PQGYDIIRTW LYYSLLRAYL LYGDVPFRYV RINGMGLDEK GEAMHKSKGN
550 560 570 580 590 600
VIDLLAPVEK YGADPVRFWA AAAGRLGTDY RYNENVIREG KEFLTKVWNI SRFVLSFPEP
610 620 630 640 650 660
QQKPQLAPVD RALLARLYDV AKKVITAYSE FDVYEPAHAL YNFIWHEFAD HYIELVKSRA
670 680 690 700 710 720
YNREGVFTEE EQRAAIWTLY TAWRYSLKLL APIMPFVTDK IWREAYGRSI HDEMIEDPPE
730 740 750 760 770 780
EWKEGDQALF HLVKKINSAV WRYKNRRGMS LADRLDAVLY VSELAMQAAK DLKYMHKVSD
790
VRPGRGAEQI DDEGLVWLG