Q8ZU97
Gene name |
argG |
Protein name |
Argininosuccinate synthase |
Names |
Citrulline--aspartate ligase |
Species |
Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2) |
KEGG Pathway |
pai:PAE2884 |
EC number |
6.3.4.5: Other carbon--nitrogen ligases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8ZU97
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8ZU97-F1 | Predicted | AlphaFoldDB |
No variants for Q8ZU97
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q8ZU97 | |||||
No associated diseases with Q8ZU97
2 regional properties for Q8ZU97
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Argininosuccinate synthase, conserved site | 9 - 17 | IPR018223-1 |
| conserved_site | Argininosuccinate synthase, conserved site | 117 - 128 | IPR018223-2 |
Functions
| Description | ||
|---|---|---|
| EC Number | 6.3.4.5 | Other carbon--nitrogen ligases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| argininosuccinate synthase activity | Catalysis of the reaction: ATP + L-citrulline + L-aspartate = AMP + diphosphate + (N(omega)-L-arginino)succinate. |
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| arginine biosynthetic process | The chemical reactions and pathways resulting in the formation of arginine, 2-amino-5-(carbamimidamido)pentanoic acid. |
| argininosuccinate metabolic process | The chemical reactions and pathways involving argininosuccinate, 2-(N(omega)-arginino)succinate, an intermediate in the ornithine-urea cycle, where it is synthesized from citrulline and aspartate. |
| urea cycle | The sequence of reactions by which arginine is synthesized from ornithine, then cleaved to yield urea and regenerate ornithine. The overall reaction equation is NH3 + CO2 + aspartate + 3 ATP + 2 H2O = urea + fumarate + 2 ADP + 2 phosphate + AMP + diphosphate. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGASKIVLAY | SGGLDTTVAV | KWLSEKFGAE | VYTVTVDVGQ | EDDFSKIEER | AYKAGAVQHF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| YIDAKREFAE | EYIARAILMN | GMYEGVYPLG | TALARPLIAA | KVVEVARRLG | ADAVAHGSTS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KGNDQVRFDV | TVKALAPDLK | IIAPARIWGM | TRAEEIEYAK | RHGLPVGEEH | KKYSIDDNLW |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SRSIEGGPID | DPLAEPPEDA | FKWTVSPDKA | PHDPTYLTIE | FEKGLPVAVN | GEKMSLASII |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SLLNHVGGAN | GVGRIDHIEN | RLVGFKSREV | YEAPAAVILY | HAHRDLEKMV | LTPRELRFKH |
| 310 | 320 | 330 | 340 | 350 | 360 |
| YVLDPQWADL | VYQGLWVEPL | RNALEKAAEE | MERWVSGEVR | VKLYKGSLWV | VGRESPYGGY |
| 370 | 380 | 390 | |||
| SKELADYSAG | WYPSDEEARG | FIEMWSLHSL | TALRRRK |