Q8ZTP4

PR
Gene name
serS
Protein name
Serine--tRNA ligase
Names
Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase
Species
Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2)
KEGG Pathway
pai:PAE3158
EC number
6.1.1.11: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

22-122 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8ZTP4

Entry ID Method Resolution Chain Position Source
AF-Q8ZTP4-F1 Predicted AlphaFoldDB

No variants for Q8ZTP4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8ZTP4

No associated diseases with Q8ZTP4

4 regional properties for Q8ZTP4

Type Name Position InterPro Accession
domain Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) 239 - 414 IPR002314
domain Aminoacyl-tRNA synthetase, class II 200 - 425 IPR006195
domain Serine-tRNA synthetase, type1, N-terminal 7 - 107 IPR015866
domain Serine-tRNA ligase catalytic core domain 120 - 432 IPR033729

Functions

Description
EC Number 6.1.1.11 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
serine-tRNA ligase activity Catalysis of the reaction: ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser).
tRNA binding Binding to a transfer RNA.

3 GO annotations of biological process

Name Definition
selenocysteine biosynthetic process The chemical reactions and pathways resulting in the formation of selenocysteine, an essential component of glutathione peroxidase and some other proteins.
selenocysteinyl-tRNA(Sec) biosynthetic process The chemical reactions and pathways resulting in the formation of selenocysteinyl-tRNA(Sec). This process occurs through the following steps: a unique serine-tRNA with a UGA recognizing anticodon is first aminoacylated with serine; this is then phosphorylated by phosphoseryl-tRNA
seryl-tRNA aminoacylation The process of coupling serine to seryl-tRNA, catalyzed by seryl-tRNA synthetase. The seryl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a serine-accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSYSVLEALR NSPDVVRKVL TARRMDASLV DKFLELDEKW RRLKKEVDEL RHEYNKLSKE
70 80 90 100 110 120
GAKAPPERRR EIADKARELA ARLERAEKEL EETERAREEV LWSFPNLIHE SVPICPEGVD
130 140 150 160 170 180
SIPVRHWGVV KTTKDVVDKL DKGVDYLVVE KAPVGHADMA EVVLKMADTL KAGEVAGSRF
190 200 210 220 230 240
YYLFDDLVWL DFALAMYALD YLAQKGFRPV IPPYMLKYDL IRRVLDFDTF KDAIYKIDGE
250 260 270 280 290 300
DLYLIATAEH GIAAYLYKRE LLEEELPQLY VGWSPCFRKE AGAGSRDIKG IFRVHIFHKV
310 320 330 340 350 360
EQFVFSLPED SWKWHEEITK NTEELIRGLG LPYRVVNICA HDLGAPAAKK YDIEVWYPSQ
370 380 390 400 410 420
GMYRELASCS NVTDWQSYRL GIRVTRKGMK REYVHTLNCT GLATTRTITA ILENFQREDG
430 440 450
AVEIPKVLRQ YLEPIKAAPK DYILPKAAKS P