Q8ZTJ7

PR
Gene name
rnz
Protein name
Ribonuclease Z
Names
RNase Z, tRNA 3 endonuclease, tRNase Z
Species
Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2)
KEGG Pathway
pai:PAE3218
EC number
3.1.26.11: Endoribonucleases producing 5'-phosphomonoesters
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

185-287 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8ZTJ7

Entry ID Method Resolution Chain Position Source
AF-Q8ZTJ7-F1 Predicted AlphaFoldDB

No variants for Q8ZTJ7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8ZTJ7

No associated diseases with Q8ZTJ7

6 regional properties for Q8ZTJ7

Type Name Position InterPro Accession
domain HD/PDEase domain 347 - 453 IPR003607
domain K Homology domain 223 - 290 IPR004087
domain K Homology domain, type 1 227 - 284 IPR004088
domain HD domain 351 - 444 IPR006674
domain HDIG domain 348 - 424 IPR006675
domain Ribonuclease Y, N-terminal 3 - 220 IPR022711

Functions

Description
EC Number 3.1.26.11 Endoribonucleases producing 5'-phosphomonoesters
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
3'-tRNA processing endoribonuclease activity Catalysis of the endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
tRNA 3'-trailer cleavage Cleavage of the 3'-end of the pre-tRNA as part of the process of generating the mature 3'-end of the tRNA; may involve endonucleolytic or exonucleolytic cleavage, or both.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MPIVKLVILG SGGAVPKADR MLPAIYLEDW LGHRVLLDAG EGVQYRLLQI GISPSSLTLI
70 80 90 100 110 120
AVTHMHEDHI LGLPGLVITS KFLGGRLKVL APKSMHGALS KLGVEVADSY EEERFKIKCV
130 140 150 160 170 180
EVCHTVDACG WLIQWDVGYK LDLSKTSGLP KWALTELIKG KPVKIGDRII TPEEVADPAH
190 200 210 220 230 240
KRFKYLLYTG DTAPCPEMWK KVGSVDVLIH EATFADDVSP SKAHEEGHST VADAIEAARA
250 260 270 280
LNAQVLILTH VSARYPDKSR HRELASRISP PPYIYIPEDF ETLLVKL