Q8ZSV6

PR
Gene name
alaS
Protein name
Alanine--tRNA ligase
Names
Alanyl-tRNA synthetase, AlaRS
Species
Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2)
KEGG Pathway
pai:PAE3565
EC number
6.1.1.7: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

438-521 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8ZSV6

Entry ID Method Resolution Chain Position Source
AF-Q8ZSV6-F1 Predicted AlphaFoldDB

No variants for Q8ZSV6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8ZSV6

No associated diseases with Q8ZSV6

3 regional properties for Q8ZSV6

Type Name Position InterPro Accession
domain Threonyl/alanyl tRNA synthetase, SAD 685 - 732 IPR012947
domain Alanyl-tRNA synthetase, class IIc, N-terminal 59 - 586 IPR018164
domain Alanyl-tRNA synthetase, class IIc, core domain 55 - 745 IPR018165

Functions

Description
EC Number 6.1.1.7 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

6 GO annotations of molecular function

Name Definition
alanine-tRNA ligase activity Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
amino acid binding Binding to an amino acid, organic acids containing one or more amino substituents.
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

2 GO annotations of biological process

Name Definition
alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA.
tRNA modification The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLSARVLKNT GFLRKQCPLC KSYFWTLRRD QEYCGDQPCV PYGFIGNPPT KISIDSLTEL
70 80 90 100 110 120
RERFLRFFER RGHARIKRYP VVARWRDDVY LVGASIYDFQ PWVTSGAVPP PANPLVISQP
130 140 150 160 170 180
SIRLTDVDKV GRSGRHLTGF EMMAHHAFNY PDKFIYWIDE TAEYAYEFFT KELGIPPEEI
190 200 210 220 230 240
TFKESIWEGG GNAGECFEVL VRGLEVATLV FMHYEVKEGK YVELPLKIVD TGYGLERIYW
250 260 270 280 290 300
LIRGTPTIYD AVFGPYLDKA RRSLGFPEPP SELMGKASVY FGQMDPEVIG LEKAYDIIAE
310 320 330 340 350 360
KIGVDPKWLR EVFKPQEALY VLADHSRTVS WMIADGVIPS NSGAGYLARL LLRRILKNLK
370 380 390 400 410 420
LVGVETPLVE LFDMHLKELK ADYPEVWEAR NLILELVDIE ERKYREILKS APGVVKKAYE
430 440 450 460 470 480
EARRRGRAGF DAEDLVSLYD SFGLPPEIVA ETAKSLGVEV KIPDDFYSRL AARHAKREKQ
490 500 510 520 530 540
PEKTLVEMAK IADLPRTREL FYEDPYMKSF KAKVLRVIDG KYVVLDQTAF YAEGGGQPAD
550 560 570 580 590 600
IGILKHGGGA AKVVDVQRVG HVIVHVVEGE APPEGSEVVG EIDWDRRYAL MKMHTGTHVL
610 620 630 640 650 660
IQSIRRVLGP HIWQAGAQKD IPASRIDVTH FKLPTAEEVA EIERLANSVV QANMPVHVKI
670 680 690 700 710 720
LPRNEAEAKY GFILYQGGVV PAREIRVVQI GPDEAPYDVQ ACGGTHLKST GEIGLIKIQK
730 740 750 760 770 780
VERIADGVVR FIFTTGLHAL KYVQEIERQV AEAASLAGGN RDNLVDSVRR LLQRAEEAER
790 800 810 820 830 840
KAQRYTELYA AEFVKNLKAE PVGKYRLAVV ELEDEELAKK VAQIATGRDK ELVLLVVGGG
850 860 870 880 890
RVTVYTGGAD VGPIVKALRE VGFRGGGSRT FAQGVYSGDV KTLIDAVKRA LA