Q8ZIM0

PR
Gene name
ileS
Protein name
Isoleucine--tRNA ligase
Names
Isoleucyl-tRNA synthetase, IleRS
Species
Yersinia pestis
KEGG Pathway
ypm:YP_3705
EC number
6.1.1.5: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-46 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8ZIM0

Entry ID Method Resolution Chain Position Source
AF-Q8ZIM0-F1 Predicted AlphaFoldDB

No variants for Q8ZIM0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8ZIM0

No associated diseases with Q8ZIM0

5 regional properties for Q8ZIM0

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 58 - 69 IPR001412
domain Aminoacyl-tRNA synthetase, class Ia 28 - 640 IPR002300
domain Zinc finger, FPG/IleRS-type 898 - 926 IPR010663
domain Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding 685 - 840 IPR013155
domain Isoleucyl tRNA synthetase type 1, anticodon-binding domain 640 - 820 IPR033708

Functions

Description
EC Number 6.1.1.5 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

5 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
isoleucine-tRNA ligase activity Catalysis of the reaction: L-isoleucine + ATP + tRNA(Ile) = L-isoleucyl-tRNA(Ile) + AMP + diphosphate + 2 H(+).
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
isoleucyl-tRNA aminoacylation The process of coupling isoleucine to isoleucyl-tRNA, catalyzed by isoleucyl-tRNA synthetase. The isoleucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a isoleucine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSDYKNTLNL PETGFPMRGD LAKREPDMLK RWYEQDLYGI IRAAKKGKKT FILHDGPPYA
70 80 90 100 110 120
NGNIHIGHSV NKILKDIIVK SKGMAGYDSP YIPGWDCHGL PIELKVEQLI GKPGEKVSAA
130 140 150 160 170 180
EFRTACRKYA AEQVEGQKKD FIRLGVLGDW DHPYLTMDFK TEANIIRALS KIIDNGHLHK
190 200 210 220 230 240
GAKPVHWCTD CGSSLAEAEV EYYDKTSQSI DVRFNAVDTA TVAAKFGVSA VNGPISLVIW
250 260 270 280 290 300
TTTPWTLPAN RAISLNAEYL YQLVQVEGEC LILAADLVES VMKRAGITQW AVLGSCTGSD
310 320 330 340 350 360
LELLRFTHPF MGFDVPAILG DHVTLDAGTG AVHTAPGHGP DDFVIGQKYG LEVANPVGPN
370 380 390 400 410 420
GCYLAGTYPT LDGLFVFKAN DVVVELLREK GALLHVEKLL HSYPCCWRHK TPIIFRATPQ
430 440 450 460 470 480
WFISMDQKGL RKQSLQEIKG VQWIPDWGQA RIETMVANRP DWCISRQRTW GVPMSLFVHK
490 500 510 520 530 540
ETEQLHPRSI ELMEEVAKRV EQDGIQAWWD LDPAEILGAD AADYVKVPDT LDVWFDSGST
550 560 570 580 590 600
HSSVVDVRPE FGGHSPDMYL EGSDQHRGWF MSSLMIATAM KGKAPYRQVL THGFTVDGQG
610 620 630 640 650 660
RKMSKSIGNT ISPQDVMNKL GGDILRLWVA STDYTGEIAV SDEILKRSAD SYRRIRNTAR
670 680 690 700 710 720
FLLANLNGFD PAQHQVKPEE MVVVDRWAVG RAQAAQAEIM EAYENYDFHL VVQRLMQFCS
730 740 750 760 770 780
VEMGSFYLDI IKDRQYTAKG DGIARRSCQT ALFHIAEALV RWMAPIMSFT ADEIWNHLPG
790 800 810 820 830 840
ERQQYVFTEE WYDGLFGLAG NESMNDTFWA ELLKVRGEVN KVLEQARSDK RIGGSLEAAV
850 860 870 880 890 900
TLYAEPELAA RLNSLQDELR FVLLTSAAKV AAYADAGNDA QQSELIAGLK ITFNKADGEK
910 920 930
CPRCWHYTQD VGLVAEHAEL CGRCVTNVAG DGEERKFA