Q8ZI61

PR
Gene name
glnE
Protein name
Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme
Names
ATP:glutamine synthetase adenylyltransferase, ATase
Species
Yersinia pestis
KEGG Pathway
ypm:YP_2968
EC number
2.7.7.42: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-53 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8ZI61

Entry ID Method Resolution Chain Position Source
AF-Q8ZI61-F1 Predicted AlphaFoldDB

No variants for Q8ZI61

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8ZI61

No associated diseases with Q8ZI61

4 regional properties for Q8ZI61

Type Name Position InterPro Accession
domain Glutamate-ammonia ligase adenylyltransferase, repeated domain 34 - 276 IPR005190-1
domain Glutamate-ammonia ligase adenylyltransferase, repeated domain 553 - 805 IPR005190-2
domain PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase 297 - 436 IPR013546-1
domain PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase 825 - 919 IPR013546-2

Functions

Description
EC Number 2.7.7.42 Nucleotidyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

4 GO annotations of molecular function

Name Definition
[glutamate-ammonia-ligase] adenylyltransferase activity Catalysis of the reaction: ATP + [L-glutamate:ammonia ligase (ADP-forming)] = diphosphate + adenylyl-[L-glutamate:ammonia ligase (ADP-forming)].
[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase Catalysis of the reaction: adenylyl-[L-glutamate:ammonia ligase (ADP-forming)] + H2O = AMP + [L-glutamate:ammonia ligase (ADP-forming)].
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
magnesium ion binding Binding to a magnesium (Mg) ion.

2 GO annotations of biological process

Name Definition
metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.
regulation of glutamine family amino acid metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLPLPSELQI QAQSIKQRFS ELPAPPDLRD EDIAVLALSD FVSDMLLIHP QWLEELHQQP
70 80 90 100 110 120
PQPQEWQYYS QWLSQALAGV QDEAALLTAL RLFRRRVMVR IAWSQVLQTS GTAETLQQLS
130 140 150 160 170 180
TLAESMIIAA RDWLYQVCCR ELGTPCNRQG VPQPLLILGM GKLGGGELNF SSDIDLIFAY
190 200 210 220 230 240
PENGQTQGGR RELDNAQFFT RLGQRLIKAL DQHTIDGFVY RVDMRLRPFG DSGPLVLSFA
250 260 270 280 290 300
ALEDYYQEQG RDWERYAMVK ARLMGGADDP YSQELRQMLR PFVFRRYIDF SVIQSLRNMK
310 320 330 340 350 360
GMIAREVRRR GLKDNIKLGA GGIREIEFIT QVFQLIRGGR EPRLQERALL PTLQAVAELG
370 380 390 400 410 420
LLPEQQVADL SGSYLFLRRL ENLLQAIADE QTQTLPNDPL NQARLAWGMG YADWAAMSTA
430 440 450 460 470 480
LENHMQAVRV VFDDLIGDET PDIGEDPSHG LYKSLWQDVL EESDLAPLTP HLEEAARRQL
490 500 510 520 530 540
LATISGFRHD VDKRTIGPRG REVLDQLMPR LFAEVCPRPD ANVALSRLIL LLLSIVTRTT
550 560 570 580 590 600
YLELLVEYHA ALKHVIRLCS ASPMVASQLA RYPLLLDELL DPQSLYQPLA PSAYRDELRQ
610 620 630 640 650 660
YLLRVPEDDE EQQLEALRQF KQAQQLRIAA GDITEALPVM KVSDHLTYLA EAIIDAVIQQ
670 680 690 700 710 720
AWNQMVARYG QPSHLQQSEG RGFAVIGYGK LGGWELGYSS DLDLVFLLDC PLDVMTDGDR
730 740 750 760 770 780
SIDGRQFYLR LAQRIMHLFS TRTSSGILYE VDARLRPSGE AGMLVSTIEA FADYQRNEAW
790 800 810 820 830 840
TWEHQALVRA RIVYGSPKLH QQFDAIRQQI LCRHREDPQL QQEVREMREK MRNHLGSKQR
850 860 870 880 890 900
DIFDIKADAG GITDIEFIAQ YLVLRYAASE PRLTRWSDNV RIFESMAHYD IMSPEEAAAL
910 920 930 940 950
TRAYVTMRDE IHHLALQEQS SKVAADSFIA EREQVAASWH KWLAANDANV S