Q8ZG15

PR
Gene name
folE
Protein name
GTP cyclohydrolase 1
Names
GTP cyclohydrolase I, GTP-CH-I
Species
Yersinia pestis
KEGG Pathway
ypm:YP_1395
EC number
3.5.4.16: In cyclic amidines
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-58 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for Q8ZG15

Entry ID Method Resolution Chain Position Source
4DU6 X-ray 211 A A/B/C/D/E 1-220 PDB
AF-Q8ZG15-F1 Predicted AlphaFoldDB

No variants for Q8ZG15

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8ZG15

No associated diseases with Q8ZG15

No regional properties for Q8ZG15

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q8ZG15

Functions

Description
EC Number 3.5.4.16 In cyclic amidines
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
GTP binding Binding to GTP, guanosine triphosphate.
GTP cyclohydrolase I activity Catalysis of the reaction: GTP + H2O = formate + 7,8-dihydroneopterin 3'-triphosphate.
zinc ion binding Binding to a zinc ion (Zn).

4 GO annotations of biological process

Name Definition
7,8-dihydroneopterin 3'-triphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of 7,8-dihydroneopterin 3'-triphosphate.
one-carbon metabolic process The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states.
tetrahydrobiopterin biosynthetic process The chemical reactions and pathways resulting in the formation of tetrahydrobiopterin, the reduced form of biopterin (2-amino-4-hydroxy-6-(1,2-dihydroxypropyl)-pteridine). It functions as a hydroxylation coenzyme, e.g. in the conversion of phenylalanine to tyrosine.
tetrahydrofolate biosynthetic process The chemical reactions and pathways resulting in the formation of tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSSLSKEAEL VHQALLARGL ETPLRKPELD AETRKTRIQA HMTEVMHLLN LDLTDDSLAD
70 80 90 100 110 120
TPRRIAKMYV DEIFSGLDYE NFPKITLIQN KMKVDEMVTV RDITLTSTCE HHFVTIDGKA
130 140 150 160 170 180
TVAYIPKDSV IGLSKINRIV QFFAQRPQVQ ERLTQQILLA LQTLLGTNNV AVSIDAVHYC
190 200 210
VKARGIRDAT SATTTTSLGG LFKSSQNTRQ EFLRAVRHHG