Q8ZBN1

PR
Gene name
pyrG
Protein name
CTP synthase
Names
Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase
Species
Yersinia pestis
KEGG Pathway
ypm:YP_0309
EC number
6.3.4.2: Other carbon--nitrogen ligases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

25-98 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8ZBN1

Entry ID Method Resolution Chain Position Source
AF-Q8ZBN1-F1 Predicted AlphaFoldDB

No variants for Q8ZBN1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8ZBN1

No associated diseases with Q8ZBN1

3 regional properties for Q8ZBN1

Type Name Position InterPro Accession
domain CTP synthase, N-terminal 5 - 266 IPR017456
domain Glutamine amidotransferase 301 - 535 IPR017926
domain CTP synthase GATase domain 290 - 533 IPR033828

Functions

Description
EC Number 6.3.4.2 Other carbon--nitrogen ligases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
CTP synthase activity Catalysis of the reaction: ATP + UTP + glutamine + H20= ADP + phosphate + CTP + glutamate.
glutaminase activity Catalysis of the reaction: L-glutamine + H2O = L-glutamate + NH3.
identical protein binding Binding to an identical protein or proteins.
metal ion binding Binding to a metal ion.

4 GO annotations of biological process

Name Definition
'de novo' CTP biosynthetic process The chemical reactions and pathways resulting in the formation of cytidine 5'-triphosphate (CTP) from simpler components.
CTP biosynthetic process The chemical reactions and pathways resulting in the formation of CTP, cytidine 5'-triphosphate.
glutamine metabolic process The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid.
pyrimidine nucleobase biosynthetic process The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTTNYIFVTG GVVSSLGKGI AAASLAAILE ARGLNVTIMK LDPYINVDPG TMSPTQHGEV
70 80 90 100 110 120
FVTEDGAETD LDLGHYERFI RTKMTRRNNF TTGRIYSEVL RKERRGDYLG ATIQVIPHIT
130 140 150 160 170 180
NAIKERIIEG GEGHDVVLVE IGGTVGDIES LPFLEAIRQM AVDVGREHTL YMHLTLVPYL
190 200 210 220 230 240
AAAGEVKTKP TQHSVKELLS IGIQPDVLIC RSDRAVPANE RAKIALFCNV PEKAVISLKD
250 260 270 280 290 300
VDSIYKIPGL LKSQGLDDYI CKRFSLTCPE ANLAEWEQVL YEESNPGGEV TIGMIGKYVE
310 320 330 340 350 360
LPDAYKSVIE ALKHGGLKNR LTVNIKLIDS QDVETRGEEM LKELDAILIP GGFGYRGVEG
370 380 390 400 410 420
KVLAARYARE HNIPYLGICL GMQVALMEFA RNVAGMENAN STEFVPDCKY PVVALITEWR
430 440 450 460 470 480
DEDGNVEIRT EESDLGGTMR VGGQQCHLTE GSLVRQMYGE PTIVERHRHR YEVNNMLLKQ
490 500 510 520 530 540
IEAAGLRVAG RSADNKLVEI IELPDHPWFV ACQFHPEFTS TPRDGHPLFA GFVKAAGDYQ
KRQVK