Q8ZBK0

PR
Gene name
cueO (YPO3409, y0777, YP_0276)
Protein name
Multicopper oxidase CueO
Names
MCO, Copper efflux oxidase, Cu efflux oxidase, Cuprous oxidase
Species
Yersinia pestis
KEGG Pathway
ypm:YP_0276
EC number
1.16.3.4: With oxygen as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-65 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8ZBK0

Entry ID Method Resolution Chain Position Source
AF-Q8ZBK0-F1 Predicted AlphaFoldDB

No variants for Q8ZBK0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8ZBK0

No associated diseases with Q8ZBK0

6 regional properties for Q8ZBK0

Type Name Position InterPro Accession
domain Multicopper oxidase, second cupredoxin domain 221 - 290 IPR001117
binding_site Multicopper oxidase, copper-binding site 514 - 525 IPR002355
conserved_site Twin-arginine translocation pathway, signal sequence 1 - 28 IPR006311
domain Multicopper oxidase, C-terminal 416 - 532 IPR011706
domain Multicopper oxidase, N-terminal 53 - 166 IPR011707
conserved_site Twin-arginine translocation pathway, signal sequence, bacterial/archaeal 1 - 23 IPR019546

Functions

Description
EC Number 1.16.3.4 With oxygen as acceptor
Subcellular Localization
  • Periplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall.

3 GO annotations of molecular function

Name Definition
copper ion binding Binding to a copper (Cu) ion.
ferroxidase activity Catalysis of the reaction: 4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.
oxidoreductase activity Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MHRRDFLKLT AALGAATSLP LWSRAALAAD FSPLPIPPLL QPDANGKINL NIQTGSVVWL
70 80 90 100 110 120
PSTATQTWGY NGNLLGPAIR LQRGKAVTID ITNALPEATT VHWHGLEIPG EVDGGPQALI
130 140 150 160 170 180
QPGAKRQVTF AVEQPAATCW FHPHTHSKTG HQVAMGLGGL VLIDDSDSET LPLPKQWGVD
190 200 210 220 230 240
DIPVILQDKL LDKHGQVDYQ LDVMTAAVGW FGDRMLTNGV PYPQQITPRG WVRLRLLNGC
250 260 270 280 290 300
NARSLNLALS DGRPMYVIAS DGGLLAEPVV VRELPILMGE RFEVLVDTRD GQSLDLVTLP
310 320 330 340 350 360
VTQMGMTLAP FDQPLPVLRI QPSLAIGSQV LPESLVVIPE LADVTGVQER WFQLMMDPKL
370 380 390 400 410 420
DMLGMQALVA RYGMKAMAGM NMNHGDMGAM DHGNRPDMSQ GKMKGMDHGT MNGAPAFNFS
430 440 450 460 470 480
HANRINGKAF SMTEPAFDAK QGKYEKWTIS GEGDMMLHPF HVHGTQFRIL TENGKPPAEH
490 500 510 520 530
RRGWKDIVRV EGARSEILVR FNYLAPASTP YMAHCHLLEH EDTGMMLGFT VSA