Q8ZBH1

PR
Gene name
valS
Protein name
Valine--tRNA ligase
Names
Valyl-tRNA synthetase, ValRS
Species
Yersinia pestis
KEGG Pathway
ypm:YP_0641
EC number
6.1.1.9: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-145 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8ZBH1

Entry ID Method Resolution Chain Position Source
AF-Q8ZBH1-F1 Predicted AlphaFoldDB

No variants for Q8ZBH1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8ZBH1

No associated diseases with Q8ZBH1

5 regional properties for Q8ZBH1

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 56 - 67 IPR001412
domain Aminoacyl-tRNA synthetase, class Ia 28 - 645 IPR002300
domain Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding 688 - 839 IPR013155
domain Valyl-tRNA synthetase, tRNA-binding arm 900 - 958 IPR019499
domain Valyl tRNA synthetase, anticodon-binding domain 644 - 778 IPR033705

Functions

Description
EC Number 6.1.1.9 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

3 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
valine-tRNA ligase activity Catalysis of the reaction: L-valine + ATP + tRNA(Val) = L-valyl-tRNA(Val) + AMP + diphosphate + 2 H(+).

1 GO annotations of biological process

Name Definition
valyl-tRNA aminoacylation The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. The valyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a valine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MENTPSHINK TEPSLDKTYS PQEIEQPLYE HWEKQGYFKP NGDTSKESYC IMIPPPNVTG
70 80 90 100 110 120
SLHMGHAFQQ TIMDTLIRYQ RMQGKNTLWQ AGTDHAGIAT QMVVERKIAA EEGKTRHDYG
130 140 150 160 170 180
RDAFIDKIWE WKGESGGTIT RQMRRLGNSV DWERERFTMD EGLSNAVKEV FVRLHKEDLI
190 200 210 220 230 240
YRGKRLVNWD PKLRTAISDL EVENRESKGS MWHLRYPLAD GAKTAEGKDY LVVATTRPET
250 260 270 280 290 300
VLGDTGVAVN PEDPRYKDLI GKEVILPLVG RRIPILGDEH ADMEKGTGCV KITPAHDFND
310 320 330 340 350 360
YEVGKRHALP MINILTFDGD IRSEAEVFDT HGEATDAFSN AIPAQFQGLE RFAARKAVVA
370 380 390 400 410 420
EFEKLGLLEE VKPHDLTVPY GDRGGVVIEP MLTDQWYVHT APLAKVAIEA VENGEIQFVP
430 440 450 460 470 480
KQYENMYYSW MRDIQDWCIS RQLWWGHRIP AWYDEQGNVY VGRDEAEVRR DNNLGAEVAL
490 500 510 520 530 540
RQDEDVLDTW FSSGLWTFST LGWPEQTDAL KTFHPTSVVV SGFDIIFFWI ARMIMLTMHF
550 560 570 580 590 600
MKDENGKPQV PFKTVYMTGL IRDDEGQKMS KSKGNVIDPL DMVDGISLEA LLEKRTGNMM
610 620 630 640 650 660
QPQLAEKIRK RTEKQFPNGI EPHGTDALRF TLAALASTGR DINWDMKRLE GYRNFCNKLW
670 680 690 700 710 720
NASRFVLMNT EGQDCGQNGG EMVLSLADRW ILAEFNQTIK AYREAMDTYR FDLAAGILYE
730 740 750 760 770 780
FTWNQFCDWY LELTKPVMNS GSEAELRGTR HTLIQVLEAL LRLAHPIIPY ITETIWQRVK
790 800 810 820 830 840
NLKGITADTI MLQPFPEYDA SQVDEQALSD LEWIKQTIIA VRNIRAEMNI APGKPLEVML
850 860 870 880 890 900
RGANAQAQRR VLENQSFIQS LARLSSLTLL AEGDKGPVSV TKLVEGAEVL IPMAGLIDKA
910 920 930 940 950 960
TELDRLAKEV AKLDAEIERI EGKLGNEGFV ARAPEAVVAK ERERLAACAE AKQKLIEQQA
TIAAL