Q8Z7P9
Gene name |
hpcH |
Protein name |
4-hydroxy-2-oxo-heptane-1,7-dioate aldolase |
Names |
2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, HHED aldolase, 4-hydroxy-2-ketoheptane-1,7-dioate aldolase, HKHD aldolase |
Species |
Salmonella typhi |
KEGG Pathway |
sty:STY1140 |
EC number |
4.1.2.52: Aldehyde-lyases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8Z7P9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8Z7P9-F1 | Predicted | AlphaFoldDB |
No variants for Q8Z7P9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q8Z7P9 | |||||
No associated diseases with Q8Z7P9
1 regional properties for Q8Z7P9
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | HpcH/HpaI aldolase/citrate lyase domain | 15 - 240 | IPR005000 |
Functions
| Description | ||
|---|---|---|
| EC Number | 4.1.2.52 | Aldehyde-lyases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase activity | Catalysis of the reaction: 2,4-dihydroxy-hept-trans-2-ene-1,7-dioate = pyruvate + succinic semialdehyde. |
| 4-hydroxy-2-ketopimelate aldolase activity | Catalysis of the reaction: 4-hydroxy-2-ketopimelate = succinate semialdehyde + pyruvate. |
| metal ion binding | Binding to a metal ion. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| phenylacetate catabolic process | The chemical reactions and pathways resulting in the breakdown of phenylacetate. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKNAFKDALK | AGRPQIGLWL | GLANSYSAEL | LAGAGFDWLL | IDGEHAPNNV | QTVLTQLQAI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| APYPSQPVVR | PSWNDPVQIK | QLLDVGAQTL | LIPMVQNADE | ARNAVAATRY | PPAGIRGVGS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ALARASRWNR | IPDYLHQAND | AMCVLVQIET | REAMSNLASI | LDVDGIDGVF | IGPADLSADM |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GFAGNPQHPE | VQAAIENAIV | QIRAAGKAPG | ILMANEALAK | RYLELGALFV | AVGVDTTLLA |
| 250 | 260 | ||||
| RGAEALAARF | GAEKKLSGAS | GVY |