Q8Z3B6

PR
Gene name
metE
Protein name
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
Names
Cobalamin-independent methionine synthase, Methionine synthase, vitamin-B12 independent isozyme
Species
Salmonella typhi
KEGG Pathway
sty:STY3594
EC number
2.1.1.14: Methyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

361-434 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8Z3B6

Entry ID Method Resolution Chain Position Source
AF-Q8Z3B6-F1 Predicted AlphaFoldDB

No variants for Q8Z3B6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8Z3B6

No associated diseases with Q8Z3B6

2 regional properties for Q8Z3B6

Type Name Position InterPro Accession
domain Cobalamin-independent methionine synthase MetE, C-terminal/archaeal 426 - 748 IPR002629
domain Cobalamin-independent methionine synthase MetE, N-terminal 5 - 312 IPR013215

Functions

Description
EC Number 2.1.1.14 Methyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity Catalysis of the reaction: 5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = L-methionine + tetrahydropteroyltri-L-glutamate.
zinc ion binding Binding to a zinc ion (Zn).

2 GO annotations of biological process

Name Definition
methionine biosynthetic process The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins.
methylation The process in which a methyl group is covalently attached to a molecule.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTILTHTLGF PRVGLRRELK KAQESYWAGN TTREALLAVG RELRARHWEQ QKQAGIDLLP
70 80 90 100 110 120
VGDFAWYDHV LTTSLLLGNV PARHQNNDGS VDIDTLFRIG RGRAPTGEPA AAAEMTKWFN
130 140 150 160 170 180
TNYHYIVPEF SKGQQFRLTW TQLLEEVDEA LALGHKIKPV LLGPVTYLWL GKVKGEPFDR
190 200 210 220 230 240
LTLLKDILPV YQHVLAELAK RGVEWVQIDE PALVLELPQA WLDAFKPAYD ALAGQVKLLL
250 260 270 280 290 300
TTYFEGVTPN LDTIIVLPVQ GLHVDLIHGK DDVVELHQRL PVDWLLSAGL INGRNVWRAD
310 320 330 340 350 360
LTEKYAQINA IVGKRALWVA SSCSLLHSPI DLSVETRLDT EVKSWFAFAL QKCGELALLR
370 380 390 400 410 420
DALNSGETAA LEEWSVPIQA RRHSHRVHNA AVEKRLAAIT AQDSQRENPY EVRAEAQRAR
430 440 450 460 470 480
FKLPAWPTTT IGSFPQTTEI RGLRLDFKKG NLDANNYRTG IAEHIKQAII EQERLGLDVL
490 500 510 520 530 540
VHGEAERNDM VEYFGEHLDG FVFTQNGWVQ SYGSRCVKPP VVIGDISRPA PITVEWAKYA
550 560 570 580 590 600
QSLTDKPVKG MLTGPVTILC WSFPREDVTR ETIAKQIALA LRDEVADLEA AGIGIIQIDE
610 620 630 640 650 660
PALREGLPLR RSDWDAYLEW GVEAFRINAA VAKDETQIHT HMCYCEFNDI MDSIAALDAD
670 680 690 700 710 720
VITIETSRSD MELLESFEAF DYPNEIGPGV YDIHSPNVPS VEWIEALLKK AAQRIPAQRL
730 740 750
WVNPDCGLKT RGWPETRAAL ANMVKAAHNL RQAK