Q8YS09

PR
Gene name
leuS
Protein name
Leucine--tRNA ligase
Names
Leucyl-tRNA synthetase, LeuRS
Species
Nostoc sp (strain PCC 7120 / SAG 2582 / UTEX 2576)
KEGG Pathway
ana:alr3283
EC number
6.1.1.4: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

249-329 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8YS09

Entry ID Method Resolution Chain Position Source
AF-Q8YS09-F1 Predicted AlphaFoldDB

No variants for Q8YS09

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8YS09

No associated diseases with Q8YS09

6 regional properties for Q8YS09

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 42 - 53 IPR001412
domain Aminoacyl-tRNA synthetase, class Ia 437 - 593 IPR002300-1
domain Aminoacyl-tRNA synthetase, class Ia 635 - 674 IPR002300-2
domain Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding 715 - 833 IPR013155
domain Methionyl/Leucyl tRNA synthetase 40 - 172 IPR015413
domain Leucyl-tRNA synthetase, editing domain 223 - 423 IPR025709

Functions

Description
EC Number 6.1.1.4 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
leucine-tRNA ligase activity Catalysis of the reaction: L-leucine + ATP + tRNA(Leu) = AMP + diphosphate + 2 H(+) + Leu-tRNA(Leu).

1 GO annotations of biological process

Name Definition
leucyl-tRNA aminoacylation The process of coupling leucine to leucyl-tRNA, catalyzed by leucyl-tRNA synthetase. The leucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a leucine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDSRYNPATL EEKWQKTWVE LGLDKTQTQS NKPKFYALSM FPYPSGSLHM GHVRNYTITD
70 80 90 100 110 120
VIARLKRMQG YRVLHPMGWD AFGLPAENAA IDRGVPPAKW TYQNITQMRQ QLQRLGLSID
130 140 150 160 170 180
WDSEVATCSP DYYKWTQWIF LQFLQAGLAY QKEAAVNWDP IDQTVLANEQ VDNEGRSWRS
190 200 210 220 230 240
GAIVERKLLR QWFLKITDYA EELLNDLDKL TGWPERVKLM QANWIGKSSG AYLEFPIVGS
250 260 270 280 290 300
NEKIAVYTTR PDTVYGVSYV VLAPEHPLTK QVTTKTQQAA VDTFIQEVTN QSELERTAED
310 320 330 340 350 360
KPKRGIATGG KAINPFTGEE VPIWIADYVL YEYGTGAVMG VPAHDVRDFK FAQRYDLPID
370 380 390 400 410 420
FVIAAPDDVA GFDLSPTSET EEVTQVVQIE YNQAYTEPGI LINSGAFTGM TSTDAKQAIV
430 440 450 460 470 480
KYATEKGFGK ERIQYRLRDW LISRQRYWGA PIPVIHCPNC GIVPVPDKDL PVILPEEVEF
490 500 510 520 530 540
TGRGGSPLAQ LESWVNVPCP TCGTPAKRET DTMDTFIDSS WYFLRFTDAR NEAQVFESAK
550 560 570 580 590 600
TNDWMPVDQY VGGIEHAILH LLYSRFFTKV LRDRGLLNFD EPFERLLTQG MVQGLTYFNP
610 620 630 640 650 660
NKGGKDKWVP SHLVNPNDPR DPQTGEPLQR LYATMSKSKG NGVAPEDVIA KYGVDTARMF
670 680 690 700 710 720
ILFKAPPEKD LEWDEADVEG QFRFLNRVWR LVTDYVASGV NPKNKSGELS KSEKDLRRAI
730 740 750 760 770 780
HTAIQSVTED LEDDYQFNTA ISELMKLSNA LTDANGKDSR VYAEGIKTLV VLLAPFAPHI
790 800 810 820 830 840
AEELWRLLGN SESVHTQTWP AFDPAALVAD EITLVIQVNG KKRADIQVPS QADKAELEKY
850 860 870
ARESEVVQRH LEGKEIKKVI VVPGKLVNFV VG