Q8XHG1

PR
Gene name
metG (metS, CPE2524)
Protein name
Methionine--tRNA ligase
Names
Methionyl-tRNA synthetase, MetRS
Species
Clostridium perfringens (strain 13 / Type A)
KEGG Pathway
cpe:CPE2524
EC number
6.1.1.10: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

485-560 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8XHG1

Entry ID Method Resolution Chain Position Source
AF-Q8XHG1-F1 Predicted AlphaFoldDB

No variants for Q8XHG1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8XHG1

No associated diseases with Q8XHG1

7 regional properties for Q8XHG1

Type Name Position InterPro Accession
domain tRNA-binding domain 544 - 645 IPR002547
domain Methionyl-tRNA synthetase, beta subunit, C-terminal 519 - 645 IPR004495
domain Methionyl/Leucyl tRNA synthetase 6 - 151 IPR015413-1
domain Methionyl/Leucyl tRNA synthetase 154 - 361 IPR015413-2
domain Methioninyl-tRNA synthetase core domain 5 - 337 IPR033911-1
domain Methioninyl-tRNA synthetase core domain 349 - 360 IPR033911-2
domain Methionyl-tRNA synthetase, anticodon-binding domain 346 - 511 IPR041872

Functions

Description
EC Number 6.1.1.10 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
methionine-tRNA ligase activity Catalysis of the reaction: ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met).
tRNA binding Binding to a transfer RNA.

1 GO annotations of biological process

Name Definition
methionyl-tRNA aminoacylation The process of coupling methionine to methionyl-tRNA, catalyzed by methionyl-tRNA synthetase. The methionyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a methionine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MCKKPYYITT PIYYPSTNLH IGNTYTTVAA DAIARFKRLT GHEVMFLTGT DEHGQKIERI
70 80 90 100 110 120
ANEKGITPKE HVDEIVAGIK DLWKMMNISY DKFIRTTDDY HVKAVQEIFK KLYDQGDIYK
130 140 150 160 170 180
DSYEGLYCTP CESFWTETQL VNGNCPDCGR PVEKAKEEAY FFKMSKYADR LIQYIEEHPD
190 200 210 220 230 240
FIQPESRKNE MLNNFLRPGL QDLCVSRTSF TWGIPVSFDE KHVIYVWIDA LSNYITALGY
250 260 270 280 290 300
GQENQELYKK FWPADVHLIG KDILRFHTIY WPIMLMALGL ELPKQVFGHG WLLVDGGKMS
310 320 330 340 350 360
KSKGNVVDPV VLVNMFGADA VRYYLLREIP FGSDGLFNNE IFIKKVNTDL ANDLGNLLSR
370 380 390 400 410 420
TIAMVYKYFG GVIQAPTCKE PIDDELINLA LSTPGKVEAS IDALKIPEAL ESIWTLISRA
430 440 450 460 470 480
NKYIDETTPW ILAKDEEKKE RLGTVLYNLL ETLRFVSVMI SPFLTETSVK INAQLNTKVT
490 500 510 520 530 540
TWESLKEFNG TVAGDKVVKG DVIFPRIDVE EKLAELEALK PAPVKPANEE LVENPIKEEI
550 560 570 580 590 600
TIDDFDKIDL RVVKVLECEP VKKAKKLLKL KVDLGGEERQ VISGIAQYYK PEELVGKYVV
610 620 630 640
LVANLKPVKL RGELSQGMIL AAAPSDDSEL LLVNPGEMLT GSQVR