Q8X1T6

PR
Gene name
aah1 (nadA, AN6078)
Protein name
Adenine deaminase
Names
ADE, Adenine aminohydrolase, AAH
Species
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
KEGG Pathway
ani:AN6078.2
EC number
3.5.4.2: In cyclic amidines
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

10-89 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8X1T6

Entry ID Method Resolution Chain Position Source
AF-Q8X1T6-F1 Predicted AlphaFoldDB

No variants for Q8X1T6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8X1T6

No associated diseases with Q8X1T6

2 regional properties for Q8X1T6

Type Name Position InterPro Accession
domain Adenosine deaminase domain 20 - 355 IPR001365
active_site Adenosine/AMP deaminase active site 297 - 303 IPR006650

Functions

Description
EC Number 3.5.4.2 In cyclic amidines
Subcellular Localization
  • Cytoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
adenine deaminase activity Catalysis of the reaction: adenine + H2O = hypoxanthine + NH3.
zinc ion binding Binding to a zinc ion (Zn).

5 GO annotations of biological process

Name Definition
adenine catabolic process The chemical reactions and pathways resulting in the breakdown of adenine, 6-aminopurine, one of the 5 main bases found in nucleic acids and a component of numerous important derivatives of its corresponding ribonucleoside, adenosine.
hypoxanthine salvage Any process that generates hypoxanthine, 6-hydroxy purine, from derivatives of it without de novo synthesis.
nucleotide metabolic process The chemical reactions and pathways involving a nucleotide, a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic nucleotides (nucleoside cyclic phosphates).
purine nucleobase catabolic process The chemical reactions and pathways resulting in the breakdown of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine.
purine ribonucleoside monophosphate biosynthetic process The chemical reactions and pathways resulting in the formation of purine ribonucleoside monophosphate, a compound consisting of a purine base linked to a ribose sugar esterified with phosphate on the sugar.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MCPPNTPYQS QWHAFLHSLP KCEHHVHLEG CLEPPLIFSM ARKNNVSLPS PSSNPAYTSV
70 80 90 100 110 120
ETLSKRYGHF SSLDDFLSFY FIGMTVLKTQ SDFAELAWTY FKRAHAEGVH HTEVFFDPQV
130 140 150 160 170 180
HMERGLEYRV IVDGYVDGCK RAEKELGIST RLIMCFLKHL PLESAQRLYD TALNEGDLGL
190 200 210 220 230 240
DGRNPVIHGL GASSSEVGPP KDLFRPIYLG AKEKSINLTA HAGEEGDASY IAAALDMGAT
250 260 270 280 290 300
RIDHGIRLGE DPELMERVAR EEVLLTVCPV SNLQLKCVKS VAEVPIRKFL DAGVRFSINS
310 320 330 340 350 360
DDPAYFGAYI LECYCAVQEA FNLSVADWRL IAENGVKGSW IGEERKNELL WRIDECVKRF
EGVL