Q8X066
Gene name |
nop-58 (B19C19.070, NCU03396) |
Protein name |
Nucleolar protein 58 |
Names |
|
Species |
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) |
KEGG Pathway |
ncr:NCU03396 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8X066
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8X066-F1 | Predicted | AlphaFoldDB |
No variants for Q8X066
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q8X066 | |||||
No associated diseases with Q8X066
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| box C/D RNP complex | A ribonucleoprotein complex containing a box C/D type RNA that can carry out ribose-2'-O-methylation of target RNAs. Box C/D type RNAs are widespread in eukaryotes and in Archaea, suggesting that an RNA-based guide mechanism for directing specific RNA 2'-O-ribose methylations was present in the common ancestor of Archaea and Eukarya. |
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| small-subunit processome | A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| snoRNA binding | Binding to a small nucleolar RNA. |
| snRNA binding | Binding to a small nuclear RNA (snRNA). |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| box C/D RNA 3'-end processing | Any process involved in forming the mature 3' end of a box C/D RNA molecule. |
| endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | Endonucleolytic cleavage within the 5'-External Transcribed Spacer (ETS) of a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. Endonucleolytic cleavage within the 5'-ETS of the pre-RNA is conserved as one of the early steps of rRNA processing in all eukaryotes, but the specific position of cleavage is variable. |
| endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | Endonucleolytic cleavage between the SSU-rRNA and the 5.8S rRNA of an rRNA molecule originally produced as a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. |
| endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | Endonucleolytic cleavage between the 5'-External Transcribed Spacer (5'-ETS) and the 5' end of the SSU-rRNA of a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript, to produce the mature end of the SSU-rRNA. |
| protein localization to nucleolus | A process in which a protein is transported to, or maintained in, a location within a nucleolus. |
| snoRNA guided rRNA 2'-O-methylation | The posttranscriptional addition of methyl groups to the 2'-oxygen atom of nucleotide residues in an rRNA molecule during ribosome biogenesis using a snoRNA guide that targets the position of methylation. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPLFILTETS | AGYGLFKAAD | KKLLSSDNLA | ERLNSVEKIT | KEIKYKEFAK | FESAATALEE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| IAGVVEGKVT | PKLNSLLAEI | GNEKKVTLAV | AESKLGAAIN | KIPNLDIQPI | ADSTTTDLFR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AIRQYLPELI | PGMLPENFKE | MSLGLSHSLS | RHKLKFSPEK | VDVMIVHAVS | LLDELDKELN |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TYAMRVKEWY | GWHFPELAKI | LPDNLSYARI | IVTMGMRSNA | TTADLSEILP | HEIEAAVKAA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ADISMGTEVS | EEDLQNIKYL | AERVIDYSVY | RKQLSDYLEN | RMRAIAPNMT | ELVGALVGAR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LIAHAGSVMN | LAKNPGSTIQ | ILGAEKALFR | ALKTKHATPK | YGLIYHASLV | GQASGANKGK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| MARQLASKVA | LGVRTDALAE | FPEDADDETR | ASLGIRSRAK | LENNLRQLEG | KPIASKGVSV |
| 430 | 440 | 450 | 460 | 470 | 480 |
| GPNGIPVASA | PKWDIKEARK | YNIDADGLAA | DAEAPKKPLI | QEVEMQDAPA | DEDEEMKDVS |
| 490 | 500 | 510 | 520 | 530 | 540 |
| KKSKKDKKEK | KEKKDKKAKK | ELDDEDFERL | AKAAGMSVDK | FKRRFERGQI | SIKEDGTLEI |
| 550 | 560 | 570 | 580 | 590 | |
| LSKKDFKGKD | AEAEEEAEEE | EKPAKKSKSS | KRKAEAEEEE | TTKEEKPKKK | KKKSSKE |