AiPD: Autoinhibited Protein Database

Q8WWF3

Gene name	SSMEM1 (C7orf45)
Protein name	Serine-rich single-pass membrane protein 1
Names
Species	Homo sapiens (Human)
KEGG Pathway	hsa:136263
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

35-244 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

35-244 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q8WWF3

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8WWF3-F1	Predicted				AlphaFoldDB

210 variants for Q8WWF3

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs756675106 CA4483023	3	D>E		No	ClinGen ExAC TOPMed gnomAD
rs750500555 CA4483022	3	D>H		No	ClinGen ExAC gnomAD
rs749707311 CA4483025	4	L>F		No	ClinGen ExAC gnomAD
CA4483026 rs749707311	4	L>I		No	ClinGen ExAC gnomAD
CA4483027 rs779288452	5	F>S		No	ClinGen ExAC gnomAD
CA369288120 rs868126292	6	S>C		No	ClinGen gnomAD
CA166906469 rs868126292	6	S>F		No	ClinGen gnomAD
CA369288128 rs1397641705	7	L>F		No	ClinGen gnomAD
CA4483028 rs746675089	8	F>C		No	ClinGen ExAC gnomAD
TCGA novel	8	F>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4483030 rs776336519	9	W>*		No	ClinGen ExAC gnomAD
rs770643207 CA4483029	9	W>*		No	ClinGen ExAC gnomAD
CA369288142 rs770643207	9	W>L		No	ClinGen ExAC gnomAD
rs111931380 CA166906485	10	E>G		No	ClinGen TOPMed
rs111931380 CA369288149	10	E>V		No	ClinGen TOPMed
rs759093657 CA4483031	12	D>E		No	ClinGen ExAC gnomAD
CA166906496 rs778451243	13	P>S		No	ClinGen Ensembl
rs186454728 CA4483032	14	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs371191805 CA166906502	14	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs766775566 CA369288177	15	P>A		No	ClinGen TOPMed gnomAD
rs766775566 CA369288179	15	P>S		No	ClinGen TOPMed gnomAD
CA166906503 rs766775566	15	P>T		No	ClinGen TOPMed gnomAD
rs148378256 CA4483033	16	I>V		No	ClinGen ESP ExAC TOPMed
rs140531337 CA4483034	18	V>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs140531337 CA369288222	18	V>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA369288213 rs1229875147	18	V>I		No	ClinGen gnomAD
rs763806644 CA4483035	20	C>W		No	ClinGen ExAC TOPMed gnomAD
rs1584710071 CA369288246	20	C>Y		No	ClinGen Ensembl
rs1455695246 CA369288258	21	A>T		No	ClinGen TOPMed
CA369288262 rs1236746023	21	A>V		No	ClinGen TOPMed
rs751298433 CA4483036	24	N>H		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	26	D>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1461391100 CA369288347	27	Y>*		No	ClinGen gnomAD
CA4483037 rs762087081	27	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA369288356 rs1240727416	28	E>A		No	ClinGen gnomAD
rs372434401 CA4483038	28	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs1193429473 CA369288369	29	C>R		No	ClinGen gnomAD
rs1475269393 CA369288396	30	W>*		No	ClinGen gnomAD
CA369288400 rs1475269393	30	W>C		No	ClinGen gnomAD
rs780147118 CA4483041	32	D>V		No	ClinGen ExAC gnomAD
CA166906544 rs968341925	33	D>N		No	ClinGen Ensembl
CA369288454 rs1432006125	34	S>F		No	ClinGen gnomAD
rs377008348 CA4483043	35	C>*		No	ClinGen ESP ExAC TOPMed gnomAD
CA369288458 rs1470344913	35	C>R		No	ClinGen gnomAD
CA4483044 rs779152211	37	T>I		No	ClinGen ExAC TOPMed gnomAD
rs977079440 CA166906550	38	I>T		No	ClinGen TOPMed gnomAD
rs1319192476 CA369288489	38	I>V		No	ClinGen gnomAD
rs1285121537 CA369288536	44	W>C		No	ClinGen gnomAD
CA369288529 rs1306836994	44	W>R		No	ClinGen TOPMed
CA369288542 rs1324275398	45	Y>C		No	ClinGen gnomAD
rs1584710193 CA369288537	45	Y>H		No	ClinGen Ensembl
TCGA novel	46	F>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	46	F>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA369288564 rs1445717237	47	V>I		No	ClinGen TOPMed
CA4483047 rs759075254	48	I>M		No	ClinGen ExAC TOPMed gnomAD
COSM1085500 CA4483049 rs764983904	49	V>I	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	53	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4483050 rs775003462	53	M>T		No	ClinGen ExAC gnomAD
rs1205390295 CA369288653	54	F>L		No	ClinGen gnomAD
rs1394216169 CA369288763	61	W>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs779494195 CA4483071	62	M>L		No	ClinGen ExAC TOPMed gnomAD
CA369289020 rs779494195	62	M>V		No	ClinGen ExAC TOPMed gnomAD
rs1486665391 CA369289029	63	S>A		No	ClinGen TOPMed
CA166910171 rs908093876	65	D>N		No	ClinGen Ensembl
CA369289074 rs1266299935	66	K>R		No	ClinGen TOPMed
rs1420962974 CA369289096	67	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs748815761 CA4483073	71	S>N		No	ClinGen ExAC gnomAD
CA4483074 rs768526884	72	G>E		No	ClinGen ExAC gnomAD
rs940965147 CA166910185	74	S>I		No	ClinGen gnomAD
CA369289186 rs940965147	74	S>N		No	ClinGen gnomAD
CA4483078 rs375103737	75	T>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
COSM3674827 CA4483077 rs375103737	75	T>S	prostate [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA369289208 rs1301226936	76	S>A		No	ClinGen gnomAD
rs1584713820 CA369289214	76	S>L		No	ClinGen Ensembl
CA369289222 rs1584713837	77	V>E		No	ClinGen Ensembl
CA4483079 rs760813474	78	R>S		No	ClinGen ExAC gnomAD
rs1451502645 CA369289685	80	A>V		No	ClinGen TOPMed
rs796391280 CA4483104	81	S>R		No	ClinGen TOPMed
rs1584715557 CA369289706	83	E>G		No	ClinGen Ensembl
rs1469538368 CA369289715	85	S>T		No	ClinGen TOPMed
rs1409447955 CA369289734	86	C>Y		No	ClinGen gnomAD
rs138196558 CA4483108	88	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA4483107 VAR_029873 rs4728190	88	R>W		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs767735134 CA4483110	91	K>E		No	ClinGen ExAC gnomAD
CA369289806 rs1271897343	91	K>R		No	ClinGen TOPMed
rs1169682645 CA369289817	92	D>H		No	ClinGen gnomAD
CA166911828 rs939163043	95	W>*		No	ClinGen TOPMed gnomAD
CA166911820 rs886231976	95	W>*		No	ClinGen TOPMed
CA4483111 rs757103154	98	S>P		No	ClinGen ExAC TOPMed gnomAD
CA369289913 rs754566893	99	Q>*		No	ClinGen ExAC gnomAD
CA4483112 rs754566893	99	Q>K		No	ClinGen ExAC gnomAD
CA4483113 rs778403297	101	M>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1313845671 CA369289965	102	K>N		No	ClinGen gnomAD
CA369289989 rs1450063119	104	P>Q		No	ClinGen gnomAD
CA4483115 rs758391833	106	Q>E		No	ClinGen ExAC TOPMed gnomAD
rs777668329 CA4483116	107	N>K		No	ClinGen ExAC gnomAD
rs373212095 CA4483117	108	Q>*		No	ClinGen ESP ExAC gnomAD
rs1012435334 CA166911866	108	Q>H		No	ClinGen TOPMed
CA166911865 rs373212095	108	Q>K		No	ClinGen ESP ExAC gnomAD
CA369290037 rs1316663250	108	Q>P		No	ClinGen TOPMed gnomAD
rs770779506 CA4483118	110	T>N		No	ClinGen ExAC gnomAD
CA369290058 rs1263881807	112	V>I		No	ClinGen gnomAD
CA4483121 rs770136220	115	S>*		No	ClinGen ExAC gnomAD
rs746103152 CA4483120	115	S>T		No	ClinGen ExAC gnomAD
CA4483122 rs376191555	116	E>K		No	ClinGen ESP ExAC gnomAD
CA369290108 rs1562907669	118	A>G		No	ClinGen Ensembl
rs1446460169 CA369290135	122	A>G		No	ClinGen gnomAD
rs868320037 CA166911928	123	Y>C		No	ClinGen TOPMed
CA369290136 rs1177033442	123	Y>N		No	ClinGen gnomAD
rs1193793367 CA369290149	125	E>K		No	ClinGen TOPMed
CA369290158 rs762179379	126	Q>*		No	ClinGen ExAC gnomAD
CA4483127 rs762179379	126	Q>K		No	ClinGen ExAC gnomAD
rs138051879 COSM1085503 CA4483128	128	R>*	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
CA4483130 rs759255478	128	R>P		No	ClinGen ExAC TOPMed gnomAD
CA4483131 rs759255478	128	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA166911974 rs919147087	129	A>P		No	ClinGen Ensembl
CA4483132 rs752255615	131	R>C		No	ClinGen ExAC gnomAD
COSM1330081 rs191908225 CA4483134	131	R>H	ovary Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
CA4483133 rs752255615	131	R>S		No	ClinGen ExAC gnomAD
CA4483136 rs751525166	132	Q>P		No	ClinGen ExAC gnomAD
rs751525166 CA4483135	132	Q>R		No	ClinGen ExAC gnomAD
rs1407338350 CA369290216	135	F>L		No	ClinGen gnomAD
rs1284440830 CA369290232	136	N>S		No	ClinGen TOPMed gnomAD
CA369290229 rs1344219227	136	N>Y		No	ClinGen TOPMed
rs781108049 CA4483137	137	E>G		No	ClinGen ExAC TOPMed gnomAD
CA4483139 rs756452743	138	V>M		No	ClinGen ExAC gnomAD
rs139029254 CA4483140	140	Q>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA4483141 rs749482804	142	Q>K		No	ClinGen ExAC gnomAD
rs768880751 CA4483142	142	Q>R		No	ClinGen ExAC gnomAD
CA369290319 rs1356442059	143	H>R		No	ClinGen TOPMed
rs1280768316 CA369290330	144	D>G		No	ClinGen gnomAD
rs1200094246 CA369290337	145	S>R		No	ClinGen gnomAD
rs748693465 CA4483144	147	T>A		No	ClinGen ExAC TOPMed gnomAD
CA4483145 rs376077146	148	T>A		No	ClinGen ExAC TOPMed gnomAD
CA4483146 rs369782854	148	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA166912065 rs878986332	153	E>G		No	ClinGen Ensembl
rs144099660 CA4483150	154	E>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs920570977 CA369290440	154	E>D		No	ClinGen TOPMed gnomAD
CA4483149 rs144099660	154	E>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs763661744 CA4483151	157	S>*		No	ClinGen ExAC TOPMed gnomAD
CA369290476 rs763661744	157	S>L		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	158	E>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA369290516 rs1455293522	160	S>A		No	ClinGen TOPMed gnomAD
CA369290534 rs1441615486	161	S>L		No	ClinGen TOPMed
rs1434929725 CA369290588 CA369290587	163	K>N		No	ClinGen gnomAD
rs757276583 CA4483153	163	K>R		No	ClinGen ExAC gnomAD
rs201447540 CA166912119	164	E>D		No	ClinGen 1000Genomes
CA166912118 rs983488980	164	E>Q		No	ClinGen TOPMed gnomAD
CA4483154 rs767334438	164	E>V		No	ClinGen ExAC gnomAD
rs750282781 CA4483155	165	S>G		No	ClinGen ExAC
rs76189869 CA4483156	167	S>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA166912139 rs939280722	168	E>G		No	ClinGen TOPMed
CA369290703 rs1285419873	169	H>P		No	ClinGen TOPMed
CA4483157 rs779947672	170	H>N		No	ClinGen ExAC TOPMed gnomAD
CA369290721 rs779947672	170	H>Y		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	174	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA166912169 rs894992391	174	D>N		No	ClinGen TOPMed
rs749535953 CA4483159	175	S>T		No	ClinGen ExAC
CA369290851 rs755089361	178	R>W		No	ClinGen ExAC gnomAD
CA4483162 rs779119799	179	R>T		No	ClinGen ExAC
CA166912200 rs760797706	180	K>E		No	ClinGen Ensembl
CA4483163 rs748166898	180	K>N		No	ClinGen ExAC gnomAD
CA4483164 rs142633639	183	Q>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA166912216 rs766518088	186	R>S		No	ClinGen Ensembl
CA369290993 rs532958163	189	G>A		No	ClinGen TOPMed gnomAD
rs532958163 CA166912218	189	G>E		No	ClinGen TOPMed gnomAD
rs1315126882 CA369291030	192	Q>P		No	ClinGen TOPMed
rs1418432704 CA369291044	193	M>K		No	ClinGen TOPMed
CA4483166 rs150765653	194	S>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs189237675 CA4483167	195	E>*		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs189237675 CA166912219	195	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs771295690 CA4483168	198	C>*		No	ClinGen ExAC gnomAD
TCGA novel	201	C>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	205	R>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs114560708 CA4483169	206	T>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs373382166 CA4483171	208	E>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs373382166 CA4483172	208	E>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA4483173 rs761196314	209	W>L		No	ClinGen ExAC TOPMed gnomAD
rs761196314 CA369291219	209	W>S		No	ClinGen ExAC TOPMed gnomAD
rs1584715992 CA369291231	210	L>W		No	ClinGen Ensembl
rs1216663006 CA369291237	211	A>T		No	ClinGen TOPMed
CA4483174 rs144037821	211	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1584716013 CA369291250	212	H>P		No	ClinGen Ensembl
rs200313957 CA166912272	212	H>Q		No	ClinGen TOPMed gnomAD
rs1295513244 CA369291266	213	H>Q		No	ClinGen TOPMed
rs1584716030 CA369291270	214	S>P		No	ClinGen Ensembl
rs146470357 CA4483177	215	R>*		No	ClinGen ESP ExAC TOPMed gnomAD
rs140752649 CA4483178	215	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs755290556 CA4483179	216	Q>*		No	ClinGen ExAC gnomAD
CA166912282 rs969892562	216	Q>R		No	ClinGen gnomAD
CA369291293 rs1273565896	218	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA4483181 rs752865833	220	V>I		No	ClinGen ExAC TOPMed gnomAD
rs1584716053 CA369291310	221	T>P		No	ClinGen Ensembl
CA4483184 rs149669717	222	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1404413432 CA369291317	222	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA166912303 rs1053160508	223	P>L		No	ClinGen Ensembl
CA166912314 TCGA novel rs866018205	224	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs1274904390 CA369291335	225	K>Q		No	ClinGen gnomAD
rs781590501 CA4483186	226	R>I		No	ClinGen ExAC gnomAD
CA166912334 rs267601283	231	E>K		No	ClinGen Ensembl
CA4483187 rs377383665	232	S>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA4483188 rs768395125	233	S>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs761477001 CA4483190	234	I>M		No	ClinGen ExAC gnomAD
rs1408358468 CA369291428	238	N>D		No	ClinGen gnomAD
rs199661470 CA4483191	238	N>I		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	240	K>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1338504931 CA369291448	240	K>N		No	ClinGen gnomAD
CA369291453 rs1584716134	241	F>Y		No	ClinGen Ensembl
CA369291462 rs1486785261	242	S>N		No	ClinGen TOPMed
rs1584716170 CA369291499	245	F>C		No	ClinGen Ensembl

No associated diseases with Q8WWF3

No regional properties for Q8WWF3

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q8WWF3

Functions

		Description
EC Number
Subcellular Localization	Membrane ; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

1 GO annotations of cellular component

Name	Definition
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

No GO annotations of molecular function

Name	Definition
No GO annotations for molecular function

No GO annotations of biological process

Name	Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins

10	20	30	40	50	60
MGDLFSLFWE	VDPPPIPVNC	AIPNQDYECW	KDDSCGTIGS	FLLWYFVIVF	VLMFFSRASV
70	80	90	100	110	120
WMSEDKKDEG	SGTSTSVRKA	SKETSCKRQS	KDSAWDPSQT	MKKPKQNQLT	PVTNSEVALV
130	140	150	160	170	180
NAYPEQRRAR	RQSQFNEVNQ	NQHDSDTTEY	GSEESNSEAS	SWKESESEHH	PSPDSIKRRK
190	200	210	220	230	240
MAQRQRNLGS	YQMSERHCLH	CKALRTNEWL	AHHSRQKPSV	TPPMKRDSQE	ESSISDINKK

FSKF