AiPD: Autoinhibited Protein Database

Q8WWC4

Gene name	MAIP1
Protein name	m-AAA protease-interacting protein 1, mitochondrial
Names	Matrix AAA peptidase-interacting protein 1
Species	Homo sapiens (Human)
KEGG Pathway	hsa:79568
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

59-132 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

59-132 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q8WWC4

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8WWC4-F1	Predicted				AlphaFoldDB

234 variants for Q8WWC4

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs533750912 CA2046739	5	A>G		No	ClinGen 1000Genomes ExAC gnomAD
rs748413044 CA2046737	5	A>S		No	ClinGen ExAC gnomAD
CA2046738 rs533750912	5	A>V		No	ClinGen 1000Genomes ExAC gnomAD
rs747358230 CA2046740	6	R>C		No	ClinGen ExAC TOPMed gnomAD
CA350221925 rs747358230	6	R>G		No	ClinGen ExAC TOPMed gnomAD
CA2046742 rs771610145	7	L>V		No	ClinGen ExAC gnomAD
rs777192025 CA2046743	7	L>W		No	ClinGen ExAC gnomAD
rs762429046 CA2046744	8	L>V		No	ClinGen ExAC TOPMed gnomAD
rs773670429 CA2046746	9	P>L		No	ClinGen ExAC TOPMed gnomAD
rs138114112 CA2046745	9	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA350221965 rs138114112	9	P>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs767106251 CA63771135	10	Q>*		No	ClinGen ExAC TOPMed gnomAD
rs767106251 CA2046748	10	Q>E		No	ClinGen ExAC TOPMed gnomAD
CA350221988 rs1395908084	10	Q>R		No	ClinGen gnomAD
CA350222012 rs1429406346	11	F>C		No	ClinGen gnomAD
rs201435155 CA63771174	11	F>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA2046750 rs755871913	14	S>C		No	ClinGen ExAC gnomAD
CA2046751 rs766367458	15	R>G		No	ClinGen ExAC gnomAD
CA2046753 rs753797211	15	R>L		No	ClinGen ExAC TOPMed gnomAD
rs753797211 CA350222081	15	R>P		No	ClinGen ExAC TOPMed gnomAD
rs753797211 CA2046752	15	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1452572669 CA350222654	16	S>L		No	ClinGen TOPMed
CA350222653 rs1452572669	16	S>W		No	ClinGen TOPMed
CA350222663 rs1352645245	18	P>S		No	ClinGen gnomAD
rs201104497 CA2046757	19	C>W		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	20	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs776804166 CA2046761	23	R>Q		No	ClinGen ExAC gnomAD
rs1252442156 CA350222704	25	R>Q		No	ClinGen gnomAD
rs1181072991 CA350222711	26	T>S		No	ClinGen gnomAD
rs781313834 CA63771289	27	P>T		No	ClinGen Ensembl
rs770161992 CA2046764	28	A>T		No	ClinGen ExAC gnomAD
CA63771314 rs943915480	28	A>V		No	ClinGen Ensembl
rs773932475 CA2046765	29	V>M		No	ClinGen ExAC TOPMed gnomAD
CA350222729 rs1465989787	30	A>D		No	ClinGen gnomAD
CA63771327 rs1040987516	30	A>T		No	ClinGen TOPMed gnomAD
CA63771329 rs897119910	31	E>K		No	ClinGen Ensembl
rs1162316580 CA350222742	32	V>A		No	ClinGen TOPMed
CA63771338 rs994200441	32	V>M		No	ClinGen gnomAD
CA63771366 rs1027053468	35	P>L		No	ClinGen gnomAD
rs781492723 CA2046766	35	P>L		No	ClinGen ExAC
rs1415868522 CA350222758	35	P>S		No	ClinGen TOPMed
CA350222764 rs1346388119	36	S>L		No	ClinGen gnomAD
rs1574817682 CA350222771	37	A>G		No	ClinGen Ensembl
TCGA novel	38	T>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1574817689 CA350222773	38	T>P		No	ClinGen Ensembl
rs772846285 CA63771394	40	C>F		No	ClinGen ExAC TOPMed gnomAD
rs772846285 CA2046769	40	C>S		No	ClinGen ExAC TOPMed gnomAD
CA350222797 rs1276652482	41	Y>*		No	ClinGen gnomAD
rs760516868 CA2046770	42	F>L		No	ClinGen ExAC gnomAD
rs367784377 CA2046771	44	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA63771459 rs143660857	45	C>Y		No	ClinGen ESP
rs753507356 CA2046772	46	R>C		No	ClinGen ExAC TOPMed gnomAD
rs753507356 CA63771474	46	R>G		No	ClinGen ExAC TOPMed gnomAD
CA350222830 rs1266078180	47	L>V		No	ClinGen gnomAD
CA2046775 rs752867183	48	G>A		No	ClinGen ExAC gnomAD
rs998556244 CA63771512	50	G>R		No	ClinGen TOPMed gnomAD
rs758551827 CA350222856	51	A>G		No	ClinGen ExAC TOPMed gnomAD
rs1031278860 CA63771516	51	A>T		No	ClinGen Ensembl
rs758551827 CA2046776	51	A>V		No	ClinGen ExAC TOPMed gnomAD
CA350222879 rs1366525258	55	P>A		No	ClinGen gnomAD
CA350222880 rs1366525258	55	P>S		No	ClinGen gnomAD
rs751845535 CA350222885	56	R>*		No	ClinGen ExAC gnomAD
CA350222897 rs1291964876	58	A>T		No	ClinGen gnomAD
CA2046779 rs757489865	59	R>G		No	ClinGen ExAC gnomAD
rs1382827507 CA350222904	59	R>K		No	ClinGen gnomAD
CA350222914 rs1362939086	60	A>V		No	ClinGen gnomAD
rs1315484960 CA350222915	61	L>V		No	ClinGen TOPMed gnomAD
CA2046782 rs770380935	62	A>T		No	ClinGen ExAC
rs114873804 CA2046783	62	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1244890408 CA350222930	63	A>V		No	ClinGen gnomAD
rs747722514 CA2046784	64	S>L		No	ClinGen ExAC TOPMed
rs1264459116 CA350222946	66	L>P		No	ClinGen gnomAD
CA2046787 rs760322371	67	P>L		No	ClinGen ExAC TOPMed gnomAD
rs200309615 CA63771610	68	A>T		No	ClinGen Ensembl
CA2046788 rs376647442	69	Q>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs376647442 CA350222961	69	Q>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA2046789 rs776541062	70	G>D		No	ClinGen ExAC gnomAD
CA2046792 rs752672763	72	R>Q		No	ClinGen ExAC gnomAD
CA2046791 rs114393899	72	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA2046795 rs764274752	74	P>L		No	ClinGen ExAC TOPMed gnomAD
CA350223001 rs1559311044	76	L>F		No	ClinGen Ensembl
CA350223015 rs1386469445	78	S>G		No	ClinGen gnomAD
TCGA novel	78	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA350223018 rs1434308010	78	S>T		No	ClinGen gnomAD
CA2046796 rs751651362	79	P>S		No	ClinGen ExAC gnomAD
CA350223058 rs1488835295	82	P>L		No	ClinGen TOPMed
CA350223074 rs1311635441	84	A>P		No	ClinGen gnomAD
rs1229792622 CA350223093	85	F>L		No	ClinGen gnomAD
rs560623066 CA2046798	88	F>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1464019879 CA350223139	90	A>P		No	ClinGen gnomAD
rs527943270 CA2046799	92	P>L		No	ClinGen 1000Genomes ExAC gnomAD
CA350223172 rs1559311088	93	Q>*		No	ClinGen Ensembl
rs1346099026 CA350223215	96	Y>C		No	ClinGen TOPMed gnomAD
rs1346099026 CA350223213	96	Y>S		No	ClinGen TOPMed gnomAD
CA350223231 rs1180476189	97	S>R		No	ClinGen gnomAD
rs1282219268 CA350223243	98	T>M		No	ClinGen TOPMed
rs780668557 CA2046802	99	E>Q		No	ClinGen ExAC TOPMed gnomAD
CA350223306 rs1392302412	102	P>H		No	ClinGen TOPMed
rs140070270 CA2046803	103	Q>*		No	ClinGen ESP ExAC TOPMed gnomAD
CA2046804 rs769081538	104	Q>P		No	ClinGen ExAC TOPMed gnomAD
rs769081538 CA63771782	104	Q>R		No	ClinGen ExAC TOPMed gnomAD
CA63771811 rs911024862	106	Q>R		No	ClinGen gnomAD
CA2046806 rs746471724	107	K>T		No	ClinGen ExAC gnomAD
CA350223443 rs1345643977	109	K>E		No	ClinGen TOPMed
CA2046807 rs564384653	109	K>N		No	ClinGen 1000Genomes ExAC gnomAD
rs776147130 CA2046808	110	M>I		No	ClinGen ExAC gnomAD
rs759438298 CA2046809	111	I>M		No	ClinGen ExAC gnomAD
rs116182492 CA2046810	114	G>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1041347640 CA63771864	115	F>C		No	ClinGen gnomAD
CA350223540 rs1041347640	115	F>S		No	ClinGen gnomAD
rs763017385 CA2046812	117	N>S		No	ClinGen ExAC gnomAD
rs1314466894 CA350223588	118	P>R		No	ClinGen TOPMed gnomAD
CA63771873 rs778668741	119	I>V		No	ClinGen Ensembl
TCGA novel	121	W>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs761766581 CA2046816	124	T>I		No	ClinGen ExAC gnomAD
CA350223692 rs767845669	125	R>*		No	ClinGen ExAC gnomAD
rs750596379 CA2046819	127	K>*		No	ClinGen ExAC gnomAD
rs750596379 CA2046818	127	K>E		No	ClinGen ExAC gnomAD
CA350223725 rs1427518137	127	K>N		No	ClinGen TOPMed
rs202128623 CA2046821	129	F>L		No	ClinGen 1000Genomes ExAC gnomAD
rs1412715236 CA350223775	131	I>F		No	ClinGen gnomAD
TCGA novel	131	I>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2046822 rs755495820	133	A>V		No	ClinGen ExAC gnomAD
CA2046823 rs779364305	134	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs746598091 CA2046824	135	F>L		No	ClinGen ExAC gnomAD
CA63771958 rs906679743	136	D>E		No	ClinGen TOPMed
CA2046826 rs368017643	136	D>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA2046825 rs756709016	136	D>Y		No	ClinGen ExAC gnomAD
rs745516138 CA2046828	137	K>E		No	ClinGen ExAC gnomAD
CA350223876 rs1218011498	137	K>N		No	ClinGen gnomAD
rs1278497547 CA350223892	138	E>G		No	ClinGen gnomAD
rs1278497547 CA350223888	138	E>V		No	ClinGen gnomAD
rs1272832258 CA350223948	142	T>A		No	ClinGen gnomAD
rs1225060660 CA350223952	142	T>I		No	ClinGen gnomAD
CA2046830 rs769451930	143	E>Q		No	ClinGen ExAC gnomAD
rs775450822 COSM345267 CA2046831	146	E>*	lung [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
TCGA novel	146	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs139414213 CA2046832	148	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA63772001 rs1031665747	150	Q>*		No	ClinGen Ensembl
CA63772004 rs956983685	150	Q>R		No	ClinGen Ensembl
rs1450002002 CA350224141	151	A>S		No	ClinGen gnomAD
rs1450002002 CA350224137	151	A>T		No	ClinGen gnomAD
rs765792359 CA2046845	151	A>V		No	ClinGen ExAC
rs753158029 CA2046846	153	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA350224179 rs1347855187	154	H>Q		No	ClinGen TOPMed
CA350224174 rs1466209644	154	H>R		No	ClinGen gnomAD
rs868547638 CA63774042	154	H>Y		No	ClinGen Ensembl
rs1472984935 CA350224227	159	L>P		No	ClinGen gnomAD
CA350224264 rs1574820322	163	K>Q		No	ClinGen Ensembl
CA350224281 rs1363495298	164	F>C		No	ClinGen TOPMed
CA350224314 rs1411160333	168	E>K		No	ClinGen gnomAD
CA350224332 rs1404312428	169	E>G		No	ClinGen gnomAD
rs1269905243 CA350224340	170	L>F		No	ClinGen TOPMed
rs1320641047 CA350224344	170	L>P		No	ClinGen gnomAD
CA2046849 rs745337503	173	K>R		No	ClinGen ExAC TOPMed gnomAD
rs1319099614 CA350224383	174	E>G		No	ClinGen gnomAD
rs1279831465 CA350224450	177	H>R		No	ClinGen gnomAD
rs1302471441 CA350224487	181	E>K		No	ClinGen TOPMed
CA350224514 rs753070404	183	V>F		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	183	V>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA350224512 rs753070404	183	V>I		No	ClinGen ExAC TOPMed gnomAD
CA2046863 rs753070404	183	V>L		No	ClinGen ExAC TOPMed gnomAD
CA2046864 rs150048783	184	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA2046865 rs764643111	187	P>S		No	ClinGen ExAC TOPMed
rs1344688018 CA350224562	188	D>V		No	ClinGen TOPMed
rs1451819016 CA350224557	188	D>Y		No	ClinGen TOPMed
CA63774420 rs986786472	190	H>L		No	ClinGen TOPMed gnomAD
CA2046867 rs755678591	190	H>Q		No	ClinGen ExAC gnomAD
rs1345630694 CA350224618	193	A>T		No	ClinGen gnomAD
COSM1014632 rs1403015180 CA350224625	193	A>V	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed
CA350224631 rs1393788442	194	L>F		No	ClinGen TOPMed
rs377269745 CA2046869	195	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA2046870 rs368436352	197	N>K		No	ClinGen ESP ExAC gnomAD
rs747927542 CA2046872	198	I>T		No	ClinGen ExAC TOPMed gnomAD
CA2046871 rs778604035	198	I>V		No	ClinGen ExAC gnomAD
CA2046873 rs771950552	201	I>T		No	ClinGen ExAC gnomAD
rs200945856 CA2046874	204	T>I		No	ClinGen ExAC TOPMed gnomAD
rs1377642335 CA350224760	206	T>I		No	ClinGen gnomAD
TCGA novel	208	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs765727760 CA2046876	209	I>T		No	ClinGen ExAC gnomAD
rs747152048 CA2046875	209	I>V		No	ClinGen ExAC gnomAD
rs940123362 CA63774503	210	S>C		No	ClinGen TOPMed gnomAD
CA350224804 rs1272382659	211	I>V		No	ClinGen gnomAD
rs759785130 CA2046878	212	Y>F		No	ClinGen ExAC gnomAD
rs1004948494 CA63774519	212	Y>H		No	ClinGen TOPMed gnomAD
rs769958661 CA2046879	213	Y>C		No	ClinGen ExAC gnomAD
CA2046881 rs375544417	215	E>D		No	ClinGen ESP ExAC TOPMed gnomAD
CA350224853 rs1331700006	215	E>K		No	ClinGen TOPMed gnomAD
CA63774544 rs1037804279	216	K>T		No	ClinGen Ensembl
TCGA novel	217	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2046899 rs763283220	218	R>G		No	ClinGen ExAC TOPMed gnomAD
rs769075871 CA2046900	218	R>M		No	ClinGen ExAC gnomAD
rs1425796260 TCGA novel CA350226106	218	R>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA ClinGen TOPMed
CA350226127 rs1180631666	219	K>N		No	ClinGen TOPMed
rs1291877038 CA350226160	221	V>I		No	ClinGen gnomAD
rs977692502 CA63775861	222	N>Y		No	ClinGen Ensembl
rs774786100 CA2046902	225	M>R		No	ClinGen ExAC gnomAD
CA2046903 rs372424449	226	C>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs776329944 CA2046905	231	T>I		No	ClinGen ExAC gnomAD
rs752410100 CA350226345	234	N>I		No	ClinGen ExAC TOPMed gnomAD
CA2046908 rs752410100	234	N>S		No	ClinGen ExAC TOPMed gnomAD
CA2046909 rs147805097	237	S>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs763981865 CA2046911	240	L>S		No	ClinGen ExAC gnomAD
rs1319390429 CA350226402	240	L>V		No	ClinGen TOPMed
rs1250435567 CA350226432	243	A>G		No	ClinGen gnomAD
rs1574821757 CA350226442	244	S>I		No	ClinGen Ensembl
CA2046913 rs757238753	247	Q>*		No	ClinGen ExAC
CA350226478 rs1186305128	247	Q>L		No	ClinGen gnomAD
rs912238658 CA63775926	248	V>I		No	ClinGen TOPMed
CA2046915 rs376452416	259	Q>*		No	ClinGen ESP ExAC TOPMed gnomAD
rs971355743 CA63775944	262	S>T		No	ClinGen Ensembl
rs1457817081 CA350226619	263	A>T		No	ClinGen gnomAD
CA2046916 rs756203672	264	S>N		No	ClinGen ExAC gnomAD
CA63775989 rs146994812	266	E>G		No	ClinGen ESP
CA350226672 rs1291566688	268	Q>R		No	ClinGen TOPMed
rs749274744 CA2046936	269	R>S		No	ClinGen ExAC gnomAD
rs755276377 CA2046937	270	E>D		No	ClinGen ExAC gnomAD
rs1285941828 CA350226704	273	Q>*		No	ClinGen gnomAD
CA2046939 rs748588415	273	Q>R		No	ClinGen ExAC gnomAD
rs373907210 CA2046941	274	G>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA2046940 rs373907210	274	G>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA350226743 rs1279973138	279	W>*		No	ClinGen gnomAD
rs775115912 CA2046944	279	W>G		No	ClinGen ExAC gnomAD
CA350226762 rs1385058236	281	I>M		No	ClinGen TOPMed
CA350226760 rs1467567350	281	I>T		No	ClinGen Ensembl
CA350226766 rs1469660172	282	A>G		No	ClinGen gnomAD
CA2046947 rs140885188	282	A>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs115358893 CA2046949	283	R>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs115358893 CA2046950	283	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA2046948 rs377424592	283	R>W		No	ClinGen ExAC TOPMed gnomAD
COSM1014635 CA63777376 rs1048972908	285	E>K	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated Ensembl NCI-TCGA
CA350226789 rs1490252519	286	H>L		No	ClinGen gnomAD
VAR_034911 CA2046953 rs2118548	290	L>I		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA350226831 rs1184049618	292	E>L		No	ClinGen TOPMed

No associated diseases with Q8WWC4

No regional properties for Q8WWC4

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q8WWC4

Functions

		Description
EC Number
Subcellular Localization	Mitochondrion matrix
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

2 GO annotations of cellular component

Name	Definition
mitochondrial inner membrane	The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
mitochondrial matrix	The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.

1 GO annotations of molecular function

Name	Definition
ribosome binding	Binding to a ribosome.

5 GO annotations of biological process

Name	Definition
calcium import into the mitochondrion	A process in which a calcium ion (Ca2+) is transported from the cytosol into the mitochondrial matrix.
inner mitochondrial membrane organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the mitochondrial inner membrane.
mitochondrial calcium ion homeostasis	Any process involved in the maintenance of an internal steady state of calcium ions within the cytoplasm of a cell or between mitochondria and their surroundings.
protein insertion into mitochondrial inner membrane from matrix	The process in which a protein is incorporated into the mitochondrial inner membrane from the matrix side. This includes membrane insertion of newly synthesized mitochondrially-encoded proteins, and insertion of nuclear-encoded proteins after their import into the mitochondrial matrix.
protein insertion into mitochondrial membrane	The process that results in the incorporation of a protein into a mitochondrial membrane.

No homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins

10	20	30	40	50	60
MALAARLLPQ	FLHSRSLPCG	AVRLRTPAVA	EVRLPSATLC	YFCRCRLGLG	AALFPRSARA
70	80	90	100	110	120
LAASALPAQG	SRWPVLSSPG	LPAAFASFPA	CPQRSYSTEE	KPQQHQKTKM	IVLGFSNPIN
130	140	150	160	170	180
WVRTRIKAFL	IWAYFDKEFS	ITEFSEGAKQ	AFAHVSKLLS	QCKFDLLEEL	VAKEVLHALK
190	200	210	220	230	240
EKVTSLPDNH	KNALAANIDE	IVFTSTGDIS	IYYDEKGRKF	VNILMCFWYL	TSANIPSETL
250	260	270	280	290
RGASVFQVKL	GNQNVETKQL	LSASYEFQRE	FTQGVKPDWT	IARIEHSKLL	E