Q8WP28

PR
Gene name
HIPK4 (QtsA-20664)
Protein name
Homeodomain-interacting protein kinase 4
Names
Species
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
KEGG Pathway
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

313-616 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8WP28

Entry ID Method Resolution Chain Position Source
AF-Q8WP28-F1 Predicted AlphaFoldDB

No variants for Q8WP28

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8WP28

No associated diseases with Q8WP28

3 regional properties for Q8WP28

Type Name Position InterPro Accession
domain Protein kinase domain 11 - 347 IPR000719
active_site Serine/threonine-protein kinase, active site 132 - 144 IPR008271
binding_site Protein kinase, ATP binding site 17 - 40 IPR017441

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

1 GO annotations of biological process

Name Definition
protein phosphorylation The process of introducing a phosphate group on to a protein.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MATTQSETDC YDIIEVLGKG TFGEVAKGWR RSTGEMVAIK ILKNDAYRNR IIKNELKLLH
70 80 90 100 110 120
CMRGLDPEEA HVIRFLEFFH DALKFYLVFE LLEQNLFEFQ KENNFAPLPA RHIRTVTLQV
130 140 150 160 170 180
LRALARLKEL AIIHADLKPE NIMLVDQTRC PFRVKVIDFG SASIFSEVRY VKEPYIQSRF
190 200 210 220 230 240
YRAPEILLGL PFCEKVDVWS LGCVMAELHL GWPLYPGNNE YDQVRYICET QGLPKPHLLH
250 260 270 280 290 300
AARKAHHFFK RNPHPDAANP WQLKSSADYL AETKVRPLER RKYMLKSLDQ IETVNGGSVA
310 320 330 340 350 360
SRLTFPDREA LAEHADLKSM VELIKRMLTW ESHERISPSA ALRHPFVSMQ QLRNAHETTH
370 380 390 400 410 420
YYQLSLRSYR LSLQVEGKPP APVVAAEDGT PYYRLAEEKE AAGMGSVASS SPFFREEKAP
430 440 450 460 470 480
GMQRAIDQLD DLSLQEAGHG LWGETCTDVV SDMMAPLKAA ITGRHMPDSG PEPILAFYSS
490 500 510 520 530 540
RLAGRHKARK PPAGSKSDSN LSNLIRLSQV SPEDDRPCRG SSWEEGEHLG ASAEPPAILQ
550 560 570 580 590 600
RDGDGPNIDN MTMEAERPDP ELFDPSSCPG EWLSEPDWTL EGVRGPRAQG LPPRRSHQHG
610
PPRGATSFLQ HVTGHH