Q8W9M6

PR
Gene name
MT-ND5 (MTND5, NADH5, ND5)
Protein name
NADH-ubiquinone oxidoreductase chain 5
Names
NADH dehydrogenase subunit 5
Species
Dugong dugon (Dugong) (Trichechus dugon)
KEGG Pathway
EC number
7.1.1.2: Hydron translocation or charge separation linked to oxidoreductase reactions
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-43 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8W9M6

Entry ID Method Resolution Chain Position Source
AF-Q8W9M6-F1 Predicted AlphaFoldDB

No variants for Q8W9M6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8W9M6

No associated diseases with Q8W9M6

9 regional properties for Q8W9M6

Type Name Position InterPro Accession
domain Thioredoxin domain 132 - 259 IPR013766-1
domain Thioredoxin domain 268 - 378 IPR013766-2
domain Thioredoxin domain 376 - 504 IPR013766-3
conserved_site Thioredoxin, conserved site 295 - 313 IPR017937-1
conserved_site Thioredoxin, conserved site 416 - 434 IPR017937-2
domain Protein disulfide-isomerase A5, N-terminal TRX-like b domain 26 - 137 IPR041865
domain Protein disulfide-isomerase A5, TRX (a) domain 150 - 254 IPR046374-1
domain Protein disulfide-isomerase A5, TRX (a) domain 275 - 377 IPR046374-2
domain Protein disulfide-isomerase A5, TRX (a) domain 396 - 499 IPR046374-3

Functions

Description
EC Number 7.1.1.2 Hydron translocation or charge separation linked to oxidoreductase reactions
Subcellular Localization
  • Mitochondrion inner membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
respirasome The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient.

1 GO annotations of molecular function

Name Definition
NADH dehydrogenase (ubiquinone) activity Catalysis of the reaction: NADH + ubiquinone + 5 H(+)(in) <=> NAD(+) + ubiquinol + 4 H(+)(out).

1 GO annotations of biological process

Name Definition
ATP synthesis coupled electron transport The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNMLPTLTLI SLIILTSPIM LSPLRIHETR NFPHYVKMAV SYAFMVSMVP AMIFMHSGHE
70 80 90 100 110 120
AVISNWHWMT IHTLKLSLSF KLDYFSLIFM PVALFVTWSI MEFSLWYMNS DPYINRFFKY
130 140 150 160 170 180
LLLFLITMII LITANNLFQL FIGWEGVGIM SFLLIGWWYG RTDANTAALQ AMIYNRIGDV
190 200 210 220 230 240
GFVAAMAWFL LHSNSWELQQ IFLTVPKGNT LPLTGLLLAA MGKSAQFGLH PWLPSAMEGP
250 260 270 280 290 300
TPVSALLHSS TMVVAGVFLL IRFHPLMEMN PSILTLTLCV GAITTLFTAI CALTQNDIKK
310 320 330 340 350 360
IIAFSTSSQL GLMMVTIGIN QPHLAFLHIC THAFFKAMLF MCSGSIIHSL GDEQDIRKMG
370 380 390 400 410 420
GLYKTLPFTT TALIIGSLAL TGMPFLTGFY SKDLIIEAMS SSYTNAWALL ITFIATSMTA
430 440 450 460 470 480
VYSTRIIFFT LLGQPRYPTL IQINENNPLL TNAIKRLMLG SIFAGFLISS NLPPTTVPPM
490 500 510 520 530 540
TMPHHLKFMA LAVTLLGFAL AIELSSFTYH LKFDYPSHTY KFSNMLGYYP TIIHRSPPHY
550 560 570 580 590 600
LLNTSQNLTS TIMDLAWLEK SIPKSLALMQ KSASTTISNQ KGMIKLYFLS FLISLTLGLL
LII