Q8W4T9
Gene name |
CYP725A2 |
Protein name |
Taxane 13-alpha-hydroxylase |
Names |
Cytochrome P450 725A2 |
Species |
Taxus cuspidata (Japanese yew) |
KEGG Pathway |
ag:AAL23619 |
EC number |
1.14.14.106: With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8W4T9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8W4T9-F1 | Predicted | AlphaFoldDB |
No variants for Q8W4T9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q8W4T9 | |||||
No associated diseases with Q8W4T9
1 regional properties for Q8W4T9
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Cytochrome P450, conserved site | 424 - 433 | IPR017972 |
Functions
| Description | ||
|---|---|---|
| EC Number | 1.14.14.106 | With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| heme binding | Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. |
| iron ion binding | Binding to an iron (Fe) ion. |
| taxane 13-alpha-hydroxylase activity | Catalysis of the reaction: H(+) + NADPH + O(2) + taxa-4(20),11-dien-5alpha-ol = H(2)O + NADP(+) + taxa-4(20),11-dien-5alpha,13alpha-diol. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| paclitaxel biosynthetic process | The chemical reactions and pathways resulting in the formation of paclitaxel, a tetracyclic diterpenoid isolated originally from the bark of the Pacific yew tree, Taxus brevifolia. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDALKQLEVS | PSILFVTLAV | MAGIILFFRS | KRHSSVKLPP | GNLGFPLVGE | TLQFVRSLGS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| STPQQFIEER | MSKFGDVFKT | SIIGHPTVVL | CGPAGNRLVL | SNENKLVQMS | WPSSMMKLIG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EDCLGGKTGE | QHRIVRAALT | RFLGPQALQN | HFAKMSSGIQ | RHINEKWKGK | DEATVLPLVK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DLVFSVASRL | FFGITEEHLQ | EQLHNLLEVI | LVGSFSVPLN | IPGFSYHKAI | QARATLADIM |
| 250 | 260 | 270 | 280 | 290 | 300 |
| THLIEKRRNE | LRAGTASENQ | DLLSVLLTFT | DERGNSLADK | EILDNFSMLL | HGSYDSTNSP |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LTMLIKVLAS | HPESYEKVAQ | EQFGILSTKM | EGEEIAWKDL | KEMKYSWQVV | QETLRMYPPI |
| 370 | 380 | 390 | 400 | 410 | 420 |
| FGTFRKAITD | IHYNGYTIPK | GWKLLWTTYS | TQTKEEYFKD | ADQFKPSRFE | EEGKHVTPYT |
| 430 | 440 | 450 | 460 | 470 | 480 |
| YLPFGGGMRV | CPGWEFAKME | TLLFLHHFVK | AFSGLKAIDP | NEKLSGKPLP | PLPVNGLPIK |
| LYSRS |