Q8W486
Gene name |
OFUT1 |
Protein name |
O-fucosyltransferase 1 |
Names |
O-FucT-1, O-fucosyltransferase family protein |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT1G04910 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8W486
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8W486-F1 | Predicted | AlphaFoldDB |
29 variants for Q8W486
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_1_1390901_C_T | 15 | G>E | No | 1000Genomes | |
| ENSVATH01013262 | 38 | S>L | No | 1000Genomes | |
| ENSVATH10597741 | 40 | L>F | No | 1000Genomes | |
| ENSVATH04521094 | 42 | S>T | No | 1000Genomes | |
| ENSVATH13853597 | 115 | R>W | No | 1000Genomes | |
| tmp_1_1389996_T_A | 135 | D>V | No | 1000Genomes | |
| tmp_1_1389681_A_T | 144 | V>D | No | 1000Genomes | |
| ENSVATH00006321 | 146 | H>R | No | 1000Genomes | |
| tmp_1_1389646_T_C | 156 | K>E | No | 1000Genomes | |
| ENSVATH13853595 | 168 | G>R | No | 1000Genomes | |
| ENSVATH13853594 | 190 | L>R | No | 1000Genomes | |
| ENSVATH04521082 | 198 | R>T | No | 1000Genomes | |
| tmp_1_1389369_T_C | 217 | D>G | No | 1000Genomes | |
| ENSVATH10597735 | 238 | H>L | No | 1000Genomes | |
| ENSVATH04521080 | 278 | N>D | No | 1000Genomes | |
| ENSVATH00006317 | 290 | K>N | No | 1000Genomes | |
| tmp_1_1388688_A_C | 325 | F>V | No | 1000Genomes | |
| ENSVATH04521075 | 342 | E>K | No | 1000Genomes | |
| ENSVATH01013260 | 343 | Q>P | No | 1000Genomes | |
| ENSVATH01013260 | 343 | Q>R | No | 1000Genomes | |
| tmp_1_1388573_G_A | 363 | P>L | No | 1000Genomes | |
| ENSVATH00006316 | 370 | T>S | No | 1000Genomes | |
| ENSVATH00006315 | 426 | P>S | No | 1000Genomes | |
| tmp_1_1388373_C_A | 430 | A>S | No | 1000Genomes | |
| ENSVATH00006313 | 471 | E>G | No | 1000Genomes | |
| ENSVATH13853592 | 490 | V>A | No | 1000Genomes | |
| tmp_1_1388177_T_C | 495 | D>G | No | 1000Genomes | |
| ENSVATH00006312 | 501 | I>V | No | 1000Genomes | |
| ENSVATH04521070 | 517 | L>V | No | 1000Genomes |
No associated diseases with Q8W486
No regional properties for Q8W486
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q8W486 | |||
7 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| endosome | A vacuole to which materials ingested by endocytosis are delivered. |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| Golgi membrane | The lipid bilayer surrounding any of the compartments of the Golgi apparatus. |
| Golgi trans cisterna | The Golgi cisterna farthest from the endoplasmic reticulum; the final processing compartment through which proteins pass before exiting the Golgi apparatus; the compartment in which N-linked protein glycosylation is completed. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| trans-Golgi network | The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| glycosyltransferase activity | Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| fucose metabolic process | The chemical reactions and pathways involving fucose, or 6-deoxygalactose, which has two enantiomers, D-fucose and L-fucose. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MRRLGHHRLH | GKTGGVGTKG | MVAKLSIGVI | VLLICTLSLL | FSANIGSNRE | PTRPSKINVE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ELWESAKSGG | WRPSSAPRSD | WPPPTKETNG | YLRVRCNGGL | NQQRSAICNA | VLAARIMNAT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LVLPELDANS | FWHDDSGFQG | IYDVEHFIET | LKYDVKIVGK | IPDVHKNGKT | KKIKAFQIRP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PRDAPIEWYL | TTALKAMREH | SAIYLTPFSH | RLAEEIDNPE | YQRLRCRVNY | HALRFKPHIM |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KLSESIVDKL | RSQGHFMSIH | LRFEMDMLAF | AGCFDIFNPE | EQKILRKYRK | ENFADKRLIY |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NERRAIGKCP | LTPEEVGLIL | RAMRFDNSTR | IYLAAGELFG | GEQFMKPFRT | LFPRLDNHSS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VDPSEELSAT | SQGLIGSAVD | YMVCLLSDIF | MPTYDGPSNF | ANNLLGHRLY | YGFRTTIRPD |
| 430 | 440 | 450 | 460 | 470 | 480 |
| RKALAPIFIA | REKGKRAGFE | EAVRRVMLKT | NFGGPHKRVS | PESFYTNSWP | ECFCQMNPKK |
| 490 | 500 | 510 | |||
| SSDKCPPNNV | IEILDSRLES | IRDPDSTSQT | NSTVTGLER |