Q8VZC9
Gene name |
VPS25 (At4g19003, F13C5) |
Protein name |
Vacuolar protein sorting-associated protein 25 |
Names |
AtVPS25, ESCRT-II complex subunit VPS25 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT4G19003 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8VZC9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8VZC9-F1 | Predicted | AlphaFoldDB |
13 variants for Q8VZC9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_4_10408550_T_A | 11 | Q>H | No | 1000Genomes | |
| tmp_4_10408363_C_A | 47 | K>N | No | 1000Genomes | |
| tmp_4_10408349_C_T | 52 | G>D | No | 1000Genomes | |
| tmp_4_10408334_A_G | 57 | F>S | No | 1000Genomes | |
| ENSVATH11998629 | 63 | S>A | No | 1000Genomes | |
| tmp_4_10408311_T_C | 65 | I>V | No | 1000Genomes | |
| tmp_4_10408204_G_A | 68 | S>F | No | 1000Genomes | |
| ENSVATH06721082 | 68 | S>T | No | 1000Genomes | |
| ENSVATH06721069 | 94 | H>Q | No | 1000Genomes | |
| ENSVATH06721068 | 102 | H>Y | No | 1000Genomes | |
| tmp_4_10407784_C_T | 140 | E>K | No | 1000Genomes | |
| ENSVATH06721057 | 161 | K>R | No | 1000Genomes | |
| ENSVATH06721056 | 179 | V>I | No | 1000Genomes |
No associated diseases with Q8VZC9
No regional properties for Q8VZC9
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q8VZC9 | |||
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| ESCRT II complex | An endosomal sorting complex required for transport and functions downstream of ESCRT I complex. It consists of the class E vacuolar protein sorting (Vps) proteins and is required for the membrane recruitment of ESCRT III complex and binds to ubiquitinated cargoes. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| protein homodimerization activity | Binding to an identical protein to form a homodimer. |
| structural molecule activity | The action of a molecule that contributes to the structural integrity of a complex or its assembly within or outside a cell. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway | The process of directing proteins towards the vacuole that contributes to protein catabolism via the multivesicular body (MVB) pathway. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MQKLADFKLP | QFFNYPPYFT | LQPVRDTREK | QIQLWKELIL | DYCKSQKIFL | IGVEEDFPLF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SNSAIDRSLS | HEARETFLSA | IVGEGRAEWL | DKGHRKCLIL | WHRIQDWADI | VLQFVRDNGL |
| 130 | 140 | 150 | 160 | 170 | |
| EDSVMTVEEI | RSGTESLGTE | LQGIDRTILM | RALKLLENKG | KLALFKGTSA | DDEGVKFSV |