Q8VYB5
Gene name |
AMSH1 (At1g48790, F11I4.4) |
Protein name |
AMSH-like ubiquitin thioesterase 1 |
Names |
Deubiquitinating enzyme AMSH1 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT1G48790 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8VYB5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8VYB5-F1 | Predicted | AlphaFoldDB |
46 variants for Q8VYB5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH01323353 | 11 | A>G | No | 1000Genomes | |
| ENSVATH14263950 | 16 | R>K | No | 1000Genomes | |
| ENSVATH13450090 | 22 | R>C | No | 1000Genomes | |
| tmp_1_18047341_G_C | 29 | F>L | No | 1000Genomes | |
| tmp_1_18046846_T_C | 46 | K>R | No | 1000Genomes | |
| tmp_1_18046527_C_G | 93 | E>D | No | 1000Genomes | |
| tmp_1_18046493_T_C | 105 | I>V | No | 1000Genomes | |
| ENSVATH04908647 | 109 | Y>D | No | 1000Genomes | |
| tmp_1_18046409_C_T | 133 | V>M | No | 1000Genomes | |
| tmp_1_18046406_T_C | 134 | K>E | No | 1000Genomes | |
| ENSVATH13450073 | 135 | P>L | No | 1000Genomes | |
| tmp_1_18046400_A_C | 136 | S>A | No | 1000Genomes | |
| ENSVATH04908644 | 137 | F>Y | No | 1000Genomes | |
| tmp_1_18046375_T_G | 144 | K>T | No | 1000Genomes | |
| ENSVATH04908641 | 148 | P>S | No | 1000Genomes | |
| tmp_1_18046175_T_A | 151 | H>L | No | 1000Genomes | |
| ENSVATH13450070 | 154 | G>A | No | 1000Genomes | |
| ENSVATH00088154 | 160 | G>A | No | 1000Genomes | |
| tmp_1_18046135_C_A | 164 | L>F | No | 1000Genomes | |
| ENSVATH04908639 | 166 | A>V | No | 1000Genomes | |
| ENSVATH14263943 | 176 | M>K | No | 1000Genomes | |
| ENSVATH01323342 | 192 | I>V | No | 1000Genomes | |
| ENSVATH14263942 | 195 | P>S | No | 1000Genomes | |
| ENSVATH04908636 | 207 | Y>N | No | 1000Genomes | |
| tmp_1_18045747_C_A | 223 | V>L | No | 1000Genomes | |
| ENSVATH00088153 | 236 | M>L | No | 1000Genomes | |
| ENSVATH04908623 | 238 | T>S | No | 1000Genomes | |
| tmp_1_18045545_T_C | 239 | N>D | No | 1000Genomes | |
| ENSVATH00088152 | 243 | D>G | No | 1000Genomes | |
| tmp_1_18045533_C_T | 243 | D>N | No | 1000Genomes | |
| ENSVATH13450063 | 244 | E>A | No | 1000Genomes | |
| ENSVATH04908621 | 246 | E>K | No | 1000Genomes | |
| tmp_1_18045482_T_C | 260 | I>V | No | 1000Genomes | |
| tmp_1_18045431_G_T | 277 | P>T | No | 1000Genomes | |
| tmp_1_18045413_T_A | 283 | N>Y | No | 1000Genomes | |
| ENSVATH04908620 | 285 | L>F | No | 1000Genomes | |
| tmp_1_18045391_G_A | 290 | S>L | No | 1000Genomes | |
| tmp_1_18045349_G_A | 304 | A>V | No | 1000Genomes | |
| tmp_1_18045335_C_T | 309 | V>I | No | 1000Genomes | |
| ENSVATH00088151 | 310 | R>K | No | 1000Genomes | |
| ENSVATH01323338 | 312 | P>L | No | 1000Genomes | |
| ENSVATH04908611 | 342 | T>A | No | 1000Genomes | |
| ENSVATH14263939 | 352 | K>T | No | 1000Genomes | |
| ENSVATH04908609 | 372 | I>V | No | 1000Genomes | |
| tmp_1_18044034_C_T | 472 | R>H | No | 1000Genomes | |
| tmp_1_18044007_T_C | 481 | E>G | No | 1000Genomes |
No associated diseases with Q8VYB5
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| Lys63-specific deubiquitinase activity | Hydrolysis of Lys63-Linked ubiquitin unit(s) from a ubiquitinated protein. |
| metal ion binding | Binding to a metal ion. |
| metal-dependent deubiquitinase activity | An metal-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| protein K48-linked deubiquitination | A protein deubiquitination process in which a K48-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is removed from a protein. |
| protein K63-linked deubiquitination | A protein deubiquitination process in which a K63-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is removed from a protein. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGSSFETIDI | ATSARRIGVD | NRISLKFYFR | IADNILKQAN | IFRAEKNVID | LYVMLLRFSS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LALETIPSHR | DYRTSLKSNK | EYLRMRLLDV | LTELEKLKPV | VQQRIDELYP | KLKPRYNVQA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| HPANGSLGWS | SAVKPSFNSY | DHAKVRNPPG | HNSGYMGSRG | QQFLNAAPLE | ERFRKMSVNF |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RPNEETLSKH | SILGPGGLSA | QWQPPKYDTK | VQYPSNIDFS | PVVIPSFQQL | VDSKPMITNG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SNDEPEKPIV | EPSVASNEKI | QKNYTEELSS | MISFEEPESV | NENNLIRQPS | PPPVLAEVQD |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LVPALCPEVR | EPECMIENSL | PDESLRSESP | LELHIATSMM | DTFMRLAKSN | TKKNLETCGI |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LAGSLKNRKF | YITALIIPKQ | ESTSDSCQAT | NEEEIFEVQD | KQSLFPLGWI | HTHPTQSCFM |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SSIDVHTHYS | YQIMLPEAVA | IVMAPQDSSR | NHGIFRLTTP | GGMTVIRNCD | RRGFHAHSSP |
| 490 | 500 | ||||
| EDGGPIYNTC | KEVYMNPNLK | FDVIDLR |