Q8VYA1
PR
Gene name |
PARG2 (At2g31865, F20M17) |
Protein name |
Probable poly(ADP-ribose) glycohydrolase 2 |
Names |
|
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT2G31865 |
EC number |
3.2.1.143: Glycosidases, ie enzymes hydrolyzing O- and S-glycosyl compounds |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8VYA1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8VYA1-F1 | Predicted | AlphaFoldDB |
52 variants for Q8VYA1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH01935817 | 3 | L>Q | No | 1000Genomes | |
| ENSVATH01935816 | 5 | A>E | No | 1000Genomes | |
| ENSVATH05640757 | 25 | W>L | No | 1000Genomes | |
| tmp_2_13549372_T_C | 34 | Q>R | No | 1000Genomes | |
| tmp_2_13549367_T_A | 36 | I>L | No | 1000Genomes | |
| tmp_2_13549319_C_T | 52 | A>T | No | 1000Genomes | |
| ENSVATH01935815 | 56 | T>M | No | 1000Genomes | |
| ENSVATH00256217 | 61 | S>F | No | 1000Genomes | |
| ENSVATH01935814 | 64 | L>M | No | 1000Genomes | |
| ENSVATH01935812 | 78 | G>A | No | 1000Genomes | |
| ENSVATH01935812 | 78 | G>V | No | 1000Genomes | |
| ENSVATH14576601 | 86 | S>Y | No | 1000Genomes | |
| ENSVATH05640750 | 91 | A>V | No | 1000Genomes | |
| tmp_2_13549043_C_G | 100 | A>P | No | 1000Genomes | |
| ENSVATH01935793 | 128 | S>F | No | 1000Genomes | |
| ENSVATH01935785 | 164 | D>Y | No | 1000Genomes | |
| ENSVATH05640741 | 166 | S>N | No | 1000Genomes | |
| tmp_2_13548660_T_C | 169 | N>S | No | 1000Genomes | |
| ENSVATH14576599 | 185 | R>C | No | 1000Genomes | |
| ENSVATH14576598 | 200 | Y>F | No | 1000Genomes | |
| ENSVATH00256212 | 207 | W>C | No | 1000Genomes | |
| ENSVATH13499420 | 207 | W>R | No | 1000Genomes | |
| tmp_2_13548455_C_T | 211 | G>S | No | 1000Genomes | |
| ENSVATH13499419 | 235 | D>N | No | 1000Genomes | |
| tmp_2_13548373_G_T | 238 | A>D | No | 1000Genomes | |
| ENSVATH01935771 | 249 | I>V | No | 1000Genomes | |
| ENSVATH13499416 | 256 | E>K | No | 1000Genomes | |
| ENSVATH13499415 | 256 | E>V | No | 1000Genomes | |
| ENSVATH14576597 | 257 | D>G | No | 1000Genomes | |
| ENSVATH00256211 | 260 | C>G | No | 1000Genomes | |
| ENSVATH13499404 | 279 | Y>H | No | 1000Genomes | |
| tmp_2_13547966_T_G | 295 | I>L | No | 1000Genomes | |
| ENSVATH05640739 | 320 | G>R | No | 1000Genomes | |
| ENSVATH05640732 | 337 | N>H | No | 1000Genomes | |
| ENSVATH05640731 | 344 | R>K | No | 1000Genomes | |
| tmp_2_13547653_T_C | 363 | Q>R | No | 1000Genomes | |
| ENSVATH13499401 | 378 | S>G | No | 1000Genomes | |
| ENSVATH05640725 | 378 | S>I | No | 1000Genomes | |
| ENSVATH05640724 | 387 | N>K | No | 1000Genomes | |
| ENSVATH13499400 | 399 | S>L | No | 1000Genomes | |
| ENSVATH05640717 | 404 | T>A | No | 1000Genomes | |
| ENSVATH05640714 | 412 | I>V | No | 1000Genomes | |
| ENSVATH13499399 | 413 | E>A | No | 1000Genomes | |
| tmp_2_13547265_C_T | 429 | V>I | No | 1000Genomes | |
| tmp_2_13547213_T_G | 446 | K>T | No | 1000Genomes | |
| ENSVATH05640706 | 453 | A>D | No | 1000Genomes | |
| ENSVATH05640702 | 474 | N>K | No | 1000Genomes | |
| ENSVATH05640699 | 490 | G>A | No | 1000Genomes | |
| ENSVATH13499395 | 497 | V>F | No | 1000Genomes | |
| tmp_2_13546849_G_A | 504 | L>F | No | 1000Genomes | |
| tmp_2_13546839_C_A | 507 | R>I | No | 1000Genomes | |
| ENSVATH05640697 | 514 | S>A | No | 1000Genomes |
No associated diseases with Q8VYA1
1 regional properties for Q8VYA1
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Poly (ADP-ribose) glycohydrolase (PARG), catalytic domain | 86 - 474 | IPR046372 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.2.1.143 | Glycosidases, ie enzymes hydrolyzing O- and S-glycosyl compounds |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| poly(ADP-ribose) glycohydrolase activity | Catalysis of the hydrolysis of poly(ADP-ribose) at glycosidic (1''-2') linkage of ribose-ribose bond to produce free ADP-ribose. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| ATP generation from poly-ADP-D-ribose | The process of generating ATP in the nucleus from poly-ADP-D-ribose. Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming. |
| carbohydrate metabolic process | The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. |
| cellular response to DNA damage stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. |
| defense response to fungus | Reactions triggered in response to the presence of a fungus that act to protect the cell or organism. |
| nucleotide-sugar metabolic process | The cellular chemical reactions and pathways involving nucleotide-sugars, any nucleotide-carbohydrate in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative. |
| regulation of DNA repair | Any process that modulates the frequency, rate or extent of DNA repair. |
| regulation of histone modification | Any process that modulates the frequency, rate or extent of the covalent alteration of a histone. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q867X0 | parg-1 | Poly(ADP-ribose) glycohydrolase 1 | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MELRADLRSI | LQYLPLVAQS | SSLVWPPSVE | EELQTISRGP | SESMVNSGEA | LALHITNMRK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SLSLNASDLA | PYALQGYGLF | FDKKISREES | ANFFGEVVPA | LCRLLLQLPS | MLEKHYQKAD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| HVLDGVKSGL | RLLGPQEAGI | VLLSQELIAA | LLACSFFCLF | PEVDRSLKNL | QGINFSGLFS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FPYMRHCTKQ | ENKIKCLIHY | FGRICRWMPT | GFVSFERKIL | PLEYHPHFVS | YPKADSWANS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VTPLCSIEIH | TSGAIEDQPC | EALEVDFADE | YFGGLTLSYD | TLQEEIRFVI | NPELIAGMIF |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LPRMDANEAI | EIVGVERFSG | YTGYGPSFQY | AGDYTDNKDL | DIFRRRKTRV | IAIDAMPDPG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| MGQYKLDALI | REVNKAFSGY | MHQCKYNIDV | KHDPEASSSH | VPLTSDSASQ | VIESSHRWCI |
| 430 | 440 | 450 | 460 | 470 | 480 |
| DHEEKKIGVA | TGNWGCGVFG | GDPELKIMLQ | WLAISQSGRP | FMSYYTFGLQ | ALQNLNQVIE |
| 490 | 500 | 510 | 520 | ||
| MVALQEMTVG | DLWKKLVEYS | SERLSRRTWL | GFFSWLMTSL | ST |