Q8VWZ7

PR
Gene name
CYP76B6 (G10H)
Protein name
Geraniol 8-hydroxylase
Names
Cytochrome P450 76B6, Geraniol 10-hydroxylase, CrG10H
Species
Catharanthus roseus (Madagascar periwinkle) (Vinca rosea)
KEGG Pathway
ag:CAC80883
EC number
1.14.14.83: With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-128 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8VWZ7

Entry ID Method Resolution Chain Position Source
AF-Q8VWZ7-F1 Predicted AlphaFoldDB

No variants for Q8VWZ7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8VWZ7

No associated diseases with Q8VWZ7

5 regional properties for Q8VWZ7

Type Name Position InterPro Accession
domain Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) 289 - 492 IPR002314
domain Anticodon-binding 513 - 602 IPR004154
domain Aminoacyl-tRNA synthetase, class II 210 - 506 IPR006195
domain Threonyl-tRNA synthetase, editing domain, archaea 1 - 139 IPR015011
domain Threonine-tRNA ligase, class IIa, anticodon-binding domain 511 - 601 IPR047246

Functions

Description
EC Number 1.14.14.83 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Subcellular Localization
  • Endoplasmic reticulum membrane ; Single-pass membrane protein
  • The N-terminal transmembrane helix is necessary and sufficient for endoplasmic reticulum targeting
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

4 GO annotations of molecular function

Name Definition
geraniol 10-hydroxylase activity Catalysis of the reaction: geraniol + O2 + NADPH + H+ <=> (6E)-8-hydroxygeraniol + NADP + H2O.
heme binding Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring.
iron ion binding Binding to an iron (Fe) ion.
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor.

1 GO annotations of biological process

Name Definition
monoterpenoid biosynthetic process The chemical reactions and pathways resulting in the formation of monoterpenoid compounds, terpenoids having a C10 skeleton.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDYLTIILTL LFALTLYEAF SYLSRRTKNL PPGPSPLPFI GSLHLLGDQP HKSLAKLSKK
70 80 90 100 110 120
HGPIMSLKLG QITTIVISSS TMAKEVLQKQ DLAFSSRSVP NALHAHNQFK FSVVWLPVAS
130 140 150 160 170 180
RWRSLRKVLN SNIFSGNRLD ANQHLRTRKV QELIAYCRKN SQSGEAVDVG RAAFRTSLNL
190 200 210 220 230 240
LSNLIFSKDL TDPYSDSAKE FKDLVWNIMV EAGKPNLVDF FPLLEKVDPQ GIRHRMTIHF
250 260 270 280 290 300
GEVLKLFGGL VNERLEQRRS KGEKNDVLDV LLTTSQESPE EIDRTHIERM CLDLFVAGTD
310 320 330 340 350 360
TTSSTLEWAM SEMLKNPDKM KKTQDELAQV IGRGKTIEES DINRLPYLRC VMKETLRIHP
370 380 390 400 410 420
PVPFLIPRKV EQSVEVCGYN VPKGSQVLVN AWAIGRDETV WDDALAFKPE RFMESELDIR
430 440 450 460 470 480
GRDFELIPFG AGRRICPGLP LALRTVPLML GSLLNSFNWK LEGGMAPKDL DMEEKFGITL
490
QKAHPLRAVP STL