Q8VI84
Gene name |
Noc3l (Ad24, Fad24) |
Protein name |
Nucleolar complex protein 3 homolog |
Names |
NOC3 protein homolog, Factor for adipocyte differentiation 24, NOC3-like protein, Nucleolar complex-associated protein 3-like protein |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:57753 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8VI84
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8VI84-F1 | Predicted | AlphaFoldDB |
45 variants for Q8VI84
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389539248 | 27 | K>T | No | EVA | |
| rs226376290 | 81 | D>E | No | EVA | |
| rs3389547241 | 94 | E>* | No | EVA | |
| rs3389543395 | 98 | Q>* | No | EVA | |
| rs3389530875 | 105 | Q>* | No | EVA | |
| rs3389539186 | 114 | L>P | No | EVA | |
| rs3389543407 | 121 | H>Y | No | EVA | |
| rs240336727 | 165 | A>S | No | EVA | |
| rs240336727 | 165 | A>T | No | EVA | |
| rs3389446297 | 167 | E>V | No | EVA | |
| rs48303150 | 171 | T>I | No | EVA | |
| rs30693899 | 173 | V>L | No | EVA | |
| rs3389493910 | 187 | E>K | No | EVA | |
| rs243748656 | 195 | K>Q | No | EVA | |
| rs3389530312 | 198 | T>S | No | EVA | |
| rs3389446266 | 216 | Q>L | No | EVA | |
| rs3389538265 | 256 | L>* | No | EVA | |
| rs3389516339 | 278 | T>I | No | EVA | |
| rs3389516383 | 279 | E>D | No | EVA | |
| rs3389530369 | 326 | S>G | No | EVA | |
| rs3389493872 | 333 | A>P | No | EVA | |
| rs265680986 | 375 | P>L | No | EVA | |
| rs3389530870 | 415 | V>I | No | EVA | |
| rs3409047704 | 421 | K>MFLTSNSGKKKHTHS* | No | EVA | |
| rs3389503607 | 452 | K>T | No | EVA | |
| rs3389550341 | 455 | T>I | No | EVA | |
| rs3389484799 | 459 | M>L | No | EVA | |
| rs3389538338 | 460 | Q>* | No | EVA | |
| rs3389550347 | 486 | K>* | No | EVA | |
| rs3389533037 | 486 | K>R | No | EVA | |
| rs3389550348 | 498 | F>L | No | EVA | |
| rs3389538339 | 522 | A>V | No | EVA | |
| rs3389503581 | 546 | S>F | No | EVA | |
| rs3389503581 | 546 | S>Y | No | EVA | |
| rs3389484786 | 572 | L>* | No | EVA | |
| rs3412776829 | 580 | Y>* | No | EVA | |
| rs3389543363 | 586 | T>I | No | EVA | |
| rs3389543383 | 598 | G>S | No | EVA | |
| rs3389530314 | 602 | V>M | No | EVA | |
| rs3389533028 | 616 | Q>P | No | EVA | |
| rs3389530908 | 725 | E>K | No | EVA | |
| rs3389537933 | 729 | R>S | No | EVA | |
| rs216280492 | 742 | A>T | No | EVA | |
| rs46713701 | 801 | Y>C | No | EVA | |
| rs3389547213 | 804 | N>I | No | EVA |
No associated diseases with Q8VI84
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
| nuclear speck | A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy. |
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| chromatin binding | Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA replication initiation | The process in which DNA-dependent DNA replication is started; this begins with the ATP dependent loading of an initiator complex onto the DNA, this is followed by DNA melting and helicase activity. In bacteria, the gene products that enable the helicase activity are loaded after the initial melting and in archaea and eukaryotes, the gene products that enable the helicase activity are inactive when they are loaded and subsequently activate. |
| fat cell differentiation | The process in which a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q8WTT2 | NOC3L | Nucleolar complex protein 3 homolog | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKARRNKKQV | PSFRKLIKTS | KVKLENKLKN | KQFKQQSTIK | KYRKEQRKLR | QAVKDAVSKK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PIPLEDPKSK | RPVKRMEREE | DEEEEALPLD | MMDEDDLQLM | KDLGQKASFL | TRDLSSSEPV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| HIKKRKHESV | IEKYEKVPRT | LQTAPEKELI | HLLPIKDKSG | IIPQAREKPV | TDVQQEEEAE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EELEDEEEVI | EDPRKELTIE | EHVIERKKKL | QDKKIQIAAL | ASAILSDPES | HIKKLKELRS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| MLMEQDPDVA | VTVRKLVIIS | LMELFKDITP | SYKIRPLTEA | EKSTKIRKET | QKLREFEEGL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VSQYKFYLEN | LEQIVKDWKQ | RKLKKSNVVS | LKAYKGLAEV | AVKSLCELLV | ALPHFNFHNN |
| 370 | 380 | 390 | 400 | 410 | 420 |
| IIVLIVPLMN | DGSKPVSEMC | CEAVKKLFKQ | DKLGQASLGV | IKVISGFVKG | RNYEVRPEML |
| 430 | 440 | 450 | 460 | 470 | 480 |
| KTFLCLRIKE | VEVKKDTEDI | NKPKRFMTFK | EKRKTLSRMQ | RKWKKAEEKL | ERELREAEAS |
| 490 | 500 | 510 | 520 | 530 | 540 |
| ESTEKKLKLH | TETLNIVFVT | YFRILKKAQK | SPLLPAVLEG | LAKFAHLINV | EFFDDLLVVL |
| 550 | 560 | 570 | 580 | 590 | 600 |
| HTLIESGELS | YQESLHCVQT | AFHILSGQGD | VLNIDPMKFY | THLYKTLFTL | HAGATNDGIE |
| 610 | 620 | 630 | 640 | 650 | 660 |
| IVLHCLDVML | SKRRKQVSHQ | RALAFIKRLC | TLALQVLPNS | SIGLLATTRI | LMHTFPRTDL |
| 670 | 680 | 690 | 700 | 710 | 720 |
| LLDNESQGSG | VFLPELEEPE | YCNAQNTALW | ELHTLRRHYH | PIVRRFAAHL | LAGAPSEGSE |
| 730 | 740 | 750 | 760 | 770 | 780 |
| ALKPELSRRS | AVELFETYSM | AAMTFNPPVE | SSHSKRKDKF | LPGDSFLNED | LNQLIKRYCN |
| 790 | 800 | ||||
| EAAPETPLDF | AKCLESSSRQ | YRVNGLS |