Q8VI38

PR
Gene name
Gbgt1
Protein name
Globoside alpha-1,3-N-acetylgalactosaminyltransferase 1
Names
Forssman glycolipid synthase
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:227671
EC number
2.4.1.88: Hexosyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

27-99 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8VI38

Entry ID Method Resolution Chain Position Source
AF-Q8VI38-F1 Predicted AlphaFoldDB

19 variants for Q8VI38

Variant ID(s) Position Change Description Diseaes Association Provenance
rs246467224 16 G>A No EVA
rs3388537855 22 V>L No EVA
rs3388539575 76 P>L No EVA
rs3388537395 85 W>L No EVA
rs3388540003 91 S>T No EVA
rs3388537783 149 H>Y No EVA
rs3388541192 151 P>H No EVA
rs230714739 171 Q>H No EVA
rs3388541289 171 Q>R No EVA
rs248185599 220 L>F No EVA
rs3391391391 253 D>E No EVA
rs3391393827 254 N>D No EVA
rs3388538909 257 D>N No EVA
rs3388534776 276 T>I No EVA
rs3388534703 288 A>G No EVA
rs3388538880 289 N>Y No EVA
rs256290907 334 R>Q No EVA
rs3388534692 347 T>I No EVA
rs3388535886 347 T>S No EVA

No associated diseases with Q8VI38

No regional properties for Q8VI38

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q8VI38

Functions

Description
EC Number 2.4.1.88 Hexosyltransferases
Subcellular Localization
  • Golgi apparatus membrane ; Single-pass type II membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
vesicle Any small, fluid-filled, spherical organelle enclosed by membrane.

2 GO annotations of molecular function

Name Definition
globoside alpha-N-acetylgalactosaminyltransferase activity Catalysis of the reaction: N-acetyl-D-galactosaminyl-(1,3)-D-galactosyl-(1,4)-D-galactosyl-(1,4)-D-glucosylceramide + UDP-N-acetylgalactosamine = N-acetyl-D-galactosaminyl-N-acetyl-D-galactosaminyl-(1,3)-D-galactosyl-(1,4)-D-galactosyl-(1,4)-D-glucosylceramide + UDP.
metal ion binding Binding to a metal ion.

4 GO annotations of biological process

Name Definition
carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
globoside metabolic process The chemical reactions and pathways involving globosides, globotetraosylceramides, ceramides containing a core structure of GalNAc-beta-(1->3)-Gal-alpha-(1->4)-Glc(I). Globosides are the major neutral glycosphingolipid in normal kidneys and erythrocytes.
lipid glycosylation Covalent attachment of a glycosyl residue to a lipid molecule.
protein glycosylation A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8N5D6 GBGT1 Globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 Homo sapiens (Human) PR
P23336 Ggta1 N-acetyllactosaminide alpha-1,3-galactosyltransferase Mus musculus (Mouse) PR
10 20 30 40 50 60
MTRPRLAQGL AFFLLGGTGL WVLWKFIKDW LLVSYIPYYL PCPEFFNMKL PFRKEKPLQP
70 80 90 100 110 120
VTQLQYPQPK LLEHGPTELL TLTPWLAPIV SEGTFDPELL KSMYQPLNLT IGVTVFAVGK
130 140 150 160 170 180
YTCFIQRFLE SAEEFFMRGY QVHYYLFTHD PTAVPRVPLG PGRLLSIIPI QGYSRWEEIS
190 200 210 220 230 240
MRRMETINKH IAKRAHKEVD YLFCVDVDMV FRNPWGPETL GDLVAAIHPG YFAVPRRKFP
250 260 270 280 290 300
YERRQVSSAF VADNEGDFYY GGALFGGRVA RVYEFTRACH MAILADKANS IMAAWQEESH
310 320 330 340
LNRHFIWHKP SKVLSPEYLW DERKPRPRSL KMIRFSSVKK NANWLRT