| apoptotic process |
A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. |
| brain development |
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.). |
| cellular response to dexamethasone stimulus |
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dexamethasone stimulus. |
| defense response to virus |
Reactions triggered in response to the presence of a virus that act to protect the cell or organism. |
| intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator |
The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage, and ends when the execution phase of apoptosis is triggered. |
| negative regulation of glycolytic process |
Any process that stops, prevents, or reduces the frequency, rate or extent of glycolysis. |
| negative regulation of intracellular signal transduction |
Any process that stops, prevents or reduces the frequency, rate or extent of intracellular signal transduction. |
| negative regulation of peptidyl-serine phosphorylation |
Any process that stops, prevents, or reduces the frequency, rate or extent of the phosphorylation of peptidyl-serine. |
| negative regulation of peptidyl-threonine phosphorylation |
Any process that decreases the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine. |
| negative regulation of TOR signaling |
Any process that stops, prevents, or reduces the frequency, rate or extent of TOR signaling. |
| neuron differentiation |
The process in which a relatively unspecialized cell acquires specialized features of a neuron. |
| neuron migration |
The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature. |
| neurotrophin TRK receptor signaling pathway |
The series of molecular signals initiated by neurotrophin binding to its receptor on the surface of a target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| positive regulation of neuron death |
Any process that activates or increases the frequency, rate or extent of neuron death. |
| protein-containing complex disassembly |
The disaggregation of a protein-containing macromolecular complex into its constituent components. |
| reactive oxygen species metabolic process |
The chemical reactions and pathways involving a reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers. |
| regulation of TOR signaling |
Any process that modulates the frequency, rate or extent of TOR signaling. |
| response to hypoxia |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. |
