AiPD: Autoinhibited Protein Database

Gene name	Wasf3 (Wave3)
Protein name	Actin-binding protein WASF3
Names	Protein WAVE-3, Wiskott-Aldrich syndrome protein family member 3, WASP family protein member 3
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:245880
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

183-277 (Predicted disordered autoinhibitory region) PR

183-277 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8VHI6-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3388804190	37	I>M	No	EVA
rs3388801140	93	Q>K	No	EVA
rs3388799453	103	S>G	No	EVA
rs3388810971	135	S>I	No	EVA
rs3388791316	147	G>R	No	EVA
rs3395640322	249	S>FL*	No	EVA
rs3388791327	250	Y>C	No	EVA
rs3396110622	250	Y>F	No	EVA
rs3395640322	250	Y>F	No	EVA
rs3396110622	250	Y>FL*	No	EVA
rs3396339809	262	P>Q	No	EVA
rs214887380	263	A>V	No	EVA
rs3388799469	266	S>F	No	EVA
rs1133249722	281	G>C	No	EVA
rs1132468871	282	A>T	No	EVA
rs1133658915	287	R>*	No	EVA
rs1132876911	288	P>L	No	EVA
rs1132208183	289	S>P	No	EVA
rs1135143513	292	S>L	No	EVA
rs1133409414	311	Q>*	No	EVA
rs1133033592	313	P>L	No	EVA
rs1134458924	316	S>F	No	EVA
rs1134285092	319	S>F	No	EVA
rs1133613304	320	T>K	No	EVA
rs3388805057	334	I>K	No	EVA
rs3388817592	355	A>S	No	EVA
rs257173936	367	T>A	No	EVA
rs3388791358	375	A>T	No	EVA
rs3388779997	376	V>I	No	EVA
rs221258608	380	P>S	No	EVA
rs264119070	414	S>T	No	EVA
rs3388810401	467	E>D	No	EVA
rs3388801144	481	I>T	No	EVA
rs49378137	493	E>A	No	EVA
rs3396410943	501	D>A	No	EVA
rs3396339743	502	D>E	No	EVA

Type	Name	Position	InterPro Accession
repeat	WD40 repeat	227 - 264	IPR001680-1
repeat	WD40 repeat	269 - 304	IPR001680-2
repeat	WD40 repeat	349 - 390	IPR001680-3
domain	BING4, C-terminal domain	441 - 519	IPR012952

		Description
EC Number
Subcellular Localization	Cytoplasm, cytoskeleton
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoskeleton	A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
glial cell projection	A prolongation or process extending from a glial cell.
glutamatergic synapse	A synapse that uses glutamate as a neurotransmitter.
lamellipodium	A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
postsynapse	The part of a synapse that is part of the post-synaptic cell.
SCAR complex	A pentameric complex that includes orthologues of human PIR121, Nap1, Abi, SCAR, and HSPC300 and regulates actin polymerization and/or depolymerization through small GTPase mediated signal transduction.

Name	Definition
actin binding	Binding to monomeric or multimeric forms of actin, including actin filaments.
Arp2/3 complex binding	Binding to an Arp2/3 complex, a protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5).
protein kinase A regulatory subunit binding	Binding to one or both of the regulatory subunits of protein kinase A.

Name	Definition
actin cytoskeleton organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
cytoskeleton organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures.
lamellipodium assembly	Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell.
modification of postsynaptic actin cytoskeleton	Any process that modifies the structure of a postsynaptic actin cytoskeleton.
oligodendrocyte development	The process aimed at the progression of an oligodendrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An oligodendrocyte is a type of glial cell involved in myelinating the axons in the central nervous system.
positive regulation of Arp2/3 complex-mediated actin nucleation	Any process that activates or increases the frequency, rate or extent of Arp2/3 complex-mediated actin nucleation.
positive regulation of myelination	Any process that activates or increases the frequency, rate or extent of the formation of a myelin sheath around nerve axons.
regulation of cell shape	Any process that modulates the surface configuration of a cell.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9Y6W5	WASF2	Actin-binding protein WASF2	Homo sapiens (Human)	PR
Q9UPY6	WASF3	Actin-binding protein WASF3	Homo sapiens (Human)	PR