Q8VEL2

PR
Gene name
Mtmr14
Protein name
Myotubularin-related protein 14
Names
mJumpy
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:97287
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-76 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8VEL2

Entry ID Method Resolution Chain Position Source
AF-Q8VEL2-F1 Predicted AlphaFoldDB

25 variants for Q8VEL2

Variant ID(s) Position Change Description Diseaes Association Provenance
rs579019284 8 A>T No EVA
rs3396819365 54 E>Q No EVA
rs3388849140 72 V>M No EVA
rs3388842891 77 N>K No EVA
rs3388856892 102 T>P No EVA
rs3388813473 249 P>S No EVA
rs3388852114 280 L>F No EVA
rs3388813499 283 P>T No EVA
rs3388842982 298 Q>H No EVA
rs3396434507 299 S>C No EVA
rs3388856866 323 S>N No EVA
rs3388835293 353 I>F No EVA
rs3388813512 384 K>I No EVA
rs3397082266 398 H>Q No EVA
rs3396825774 402 E>* No EVA
rs3388846373 423 V>M No EVA
rs3388813460 429 L>F No EVA
rs3388848927 447 V>I No EVA
rs3388829114 454 A>V No EVA
rs3388844356 456 G>R No EVA
rs3396434559 466 A>V No EVA
rs3388850224 469 G>* No EVA
rs3388856854 470 A>T No EVA
rs3397290978 521 N>K No EVA
rs3397290951 536 R>* No EVA

No associated diseases with Q8VEL2

2 regional properties for Q8VEL2

Type Name Position InterPro Accession
active_site Protein-tyrosine phosphatase, active site 327 - 337 IPR016130
domain MTMR14, PH-GRAM domain 127 - 243 IPR039803

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Found in reticular structures and plasma membrane ruffles
  • Concentrated near the nucleus (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
perinuclear region of cytoplasm Cytoplasm situated near, or occurring around, the nucleus.
ruffle Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork.

1 GO annotations of molecular function

Name Definition
phosphatidylinositol-3-phosphatase activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O = 1-phosphatidyl-1D-myo-inositol + phosphate.

1 GO annotations of biological process

Name Definition
dephosphorylation The process of removing one or more phosphoric (ester or anhydride) residues from a molecule.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8NCE2 MTMR14 Myotubularin-related protein 14 Homo sapiens (Human) PR
10 20 30 40 50 60
MAGARAAAAA SAGSTASSGS PPPQEPGLWE LLEEFSRTQY RAKDSGGKSG SKVERIEKRC
70 80 90 100 110 120
LELFGRDYCF SVIPNVNGDI CGHYPRHIVF LEYESSEKEK DTFQSTVQVN KLQDLIHRSK
130 140 150 160 170 180
MARCRGRFVC PVILFKGKHI CRSATLAGWG ELYGRSGYNY LFSGGADDTW ASTEDVTEED
190 200 210 220 230 240
FVLRSGDTHL FDKVRGYDIK LLQYLSVKYI CDLMVENKKV KFGMNVTSSE KVDKAQRYAN
250 260 270 280 290 300
FTLLSIPYPG CEFFKEYKDR DYMAEGLIFN WKQDYVDAPL NIPNFLTQSL NIDWSQYQSW
310 320 330 340 350 360
DLVQQTQNYL KLLLFIMNRD DDSGLLVHCI SGWDRTPLFI SLLRLSLWAD GLIHTSLKPA
370 380 390 400 410 420
EILYLTVAYD WFLFGHMLVD RLSKGEEIFF FCFNFLKHIT SEEFCLKTQR RKSLPTRDAG
430 440 450 460 470 480
FTVEDICMLR HKDRGSTTSL GSDFSLVLEH SPGAVGSFSY ETVELAPAGA PTQAAWRKSH
490 500 510 520 530 540
SSSPQSMLWS RPQPSEERLP SHHGLTEAKS SSSSSSNHSD NFFRMGSSPL EVPKPRSVDH
550 560 570 580 590 600
PLPGSSLSTD FGSWQLVSGC GSIQDRPVLH TDSSLPFSFQ DELPNSCLLT ALSDRETRLQ
610 620 630 640
EVRSAFLAAY SSTVGLRAAT PSPSGAIGGL LEQFARGVGL RGTSTSTL