AiPD: Autoinhibited Protein Database

Gene name	Sgip1
Protein name	SH3-containing GRB2-like protein 3-interacting protein 1
Names	Endophilin-3-interacting protein
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:73094
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

67-529 (Predicted disordered autoinhibitory region) PR

67-529 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8VD37-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3388685014	172	E>A	No	EVA
rs3388694542	177	R>T	No	EVA
rs3388697588	178	R>H	No	EVA
rs3388694554	197	L>P	No	EVA
rs3388683457	199	P>S	No	EVA
rs3388697821	288	I>M	No	EVA
rs3388701772	305	A>T	No	EVA
rs3388697522	337	P>S	No	EVA
rs32662586	355	T>P	No	EVA
rs3388696653	377	E>*	No	EVA
rs3388688953	392	Y>*	No	EVA
rs3388698414	405	G>*	No	EVA
rs3388692567	409	T>I	No	EVA
rs3388696698	447	T>N	No	EVA
rs3388688946	476	V>A	No	EVA
rs3388688946	476	V>G	No	EVA
rs3388676796	516	A>T	No	EVA
rs3388683529	563	K>E	No	EVA
rs3388697820	576	I>T	No	EVA
rs3410377145	583	N>T	No	EVA
rs3388676823	586	P>R	No	EVA
rs3388701806	603	L>M	No	EVA
rs3388697566	624	W>C	No	EVA
rs3388694667	635	K>Q	No	EVA
rs3388694636	647	Y>*	No	EVA
rs3388694576	675	E>K	No	EVA
rs3388694689	678	S>N	No	EVA
rs3388702654	793	I>F	No	EVA

Type	Name	Position	InterPro Accession
domain	Protein kinase domain	53 - 304	IPR000719
domain	Kinase associated domain 1 (KA1)	739 - 788	IPR001772
active_site	Serine/threonine-protein kinase, active site	171 - 183	IPR008271
domain	Ubiquitin-associated domain	323 - 362	IPR015940
binding_site	Protein kinase, ATP binding site	59 - 82	IPR017441
domain	Serine/threonine-protein kinase MARK 1-4, catalytic domain	52 - 304	IPR049508

		Description
EC Number
Subcellular Localization	Membrane, clathrin-coated pit ; Peripheral membrane protein ; Cytoplasmic side
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
AP-2 adaptor complex	A heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits, and links clathrin to the membrane surface of a vesicle, and the cargo receptors during receptor/clathrin mediated endocytosis. Vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC).
clathrin-coated pit	A part of the endomembrane system in the form of an invagination of a membrane upon which a clathrin coat forms, and that can be converted by vesicle budding into a clathrin-coated vesicle. Coated pits form on the plasma membrane, where they are involved in receptor-mediated selective transport of many proteins and other macromolecules across the cell membrane, in the trans-Golgi network, and on some endosomes.
clathrin-coated vesicle	A vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
presynapse	The part of a synapse that is part of the presynaptic cell.

Name	Definition
microtubule binding	Binding to a microtubule, a filament composed of tubulin monomers.
phospholipid binding	Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester.
SH3 domain binding	Binding to a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins.
tubulin binding	Binding to monomeric or multimeric forms of tubulin, including microtubules.

Name	Definition
clathrin coat assembly	The process that results in the assembly of clathrin triskelia into the ordered structure known as a clathrin cage.
clathrin-dependent endocytosis	An endocytosis process that begins when material is taken up into clathrin-coated pits, which then pinch off to form clathrin-coated endocytic vesicles.
energy homeostasis	Any process involved in the balance between food intake (energy input) and energy expenditure.
positive regulation of eating behavior	Any process that activates or increases the frequency, rate or extent of eating behavior.
positive regulation of feeding behavior	Any process that activates or increases the frequency, rate or extent of feeding behavior.
positive regulation of multicellular organism growth	Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size.
positive regulation of receptor-mediated endocytosis	Any process that activates or increases the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport.
response to dietary excess	The physiological process in which dietary excess is sensed by the central nervous system, resulting in a reduction in food intake and increased energy expenditure.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q05080	HOF1	Cytokinesis protein 2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
Q9H939	PSTPIP2	Proline-serine-threonine phosphatase-interacting protein 2	Homo sapiens (Human)	PR
O60861	GAS7	Growth arrest-specific protein 7	Homo sapiens (Human)	PR
Q9BQI5	SGIP1	SH3-containing GRB2-like protein 3-interacting protein 1	Homo sapiens (Human)	PR
P97814	Pstpip1	Proline-serine-threonine phosphatase-interacting protein 1	Mus musculus (Mouse)	PR
Q60780	Gas7	Growth arrest-specific protein 7	Mus musculus (Mouse)	PR
Q99M15	Pstpip2	Proline-serine-threonine phosphatase-interacting protein 2	Mus musculus (Mouse)	PR