Q8VC42
Gene name |
Rmc1 (Mic1, Wdr98) |
Protein name |
Regulator of MON1-CCZ1 complex |
Names |
Colon cancer-associated protein Mic1, Mic-1 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:76482 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8VC42
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8VC42-F1 | Predicted | AlphaFoldDB |
31 variants for Q8VC42
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389503263 | 11 | C>Y | No | EVA | |
| rs3389495201 | 25 | C>S | No | EVA | |
| rs3389445703 | 36 | F>L | No | EVA | |
| rs3389454583 | 62 | D>E | No | EVA | |
| rs3408065655 | 78 | I>M | No | EVA | |
| rs3389398585 | 102 | Y>C | No | EVA | |
| rs3389495167 | 134 | F>L | No | EVA | |
| rs266050240 | 138 | M>L | No | EVA | |
| rs3389398644 | 147 | L>M | No | EVA | |
| rs3389487216 | 181 | H>Q | No | EVA | |
| rs3389488405 | 240 | E>D | No | EVA | |
| rs3389466438 | 248 | R>* | No | EVA | |
| rs3389487566 | 286 | V>M | No | EVA | |
| rs3389445634 | 290 | I>F | No | EVA | |
| rs3389487632 | 291 | R>T | No | EVA | |
| rs3389398568 | 297 | D>E | No | EVA | |
| rs3389483325 | 309 | A>V | No | EVA | |
| rs259523213 | 418 | H>Y | No | EVA | |
| rs3408592579 | 432 | M>L | No | EVA | |
| rs3389503193 | 462 | T>I | No | EVA | |
| rs3389482155 | 465 | L>P | No | EVA | |
| rs3389499545 | 468 | F>L | No | EVA | |
| rs3389499540 | 469 | V>A | No | EVA | |
| rs3389483312 | 496 | P>Q | No | EVA | |
| rs3389482213 | 515 | F>L | No | EVA | |
| rs3408315728 | 519 | H>D | No | EVA | |
| rs3389490678 | 533 | L>S | No | EVA | |
| rs3389495141 | 547 | A>D | No | EVA | |
| rs3389482208 | 620 | N>S | No | EVA | |
| rs3389398609 | 625 | G>E | No | EVA | |
| rs3389445653 | 647 | G>E | No | EVA |
No associated diseases with Q8VC42
1 regional properties for Q8VC42
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Regulator of MON1-CCZ1 complex, C-terminal | 476 - 630 | IPR009755 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| late endosome membrane | The lipid bilayer surrounding a late endosome. |
| lysosomal membrane | The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm. |
| Mon1-Ccz1 complex | A protein complex that functions as a guanine nucleotide exchange factor (GEF) and converts Rab-GDP to Rab-GTP. In S. cerevisiae, this complex consists of at least Mon1 and Ccz1, and serves as a GEF for the Rab Ypt7p. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| autophagy | The cellular catabolic process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation. |
| regulation of autophagy | Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q96DM3 | RMC1 | Regulator of MON1-CCZ1 complex | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGGEDYYLEL | CERPVQFEKA | NPVNCVFFDE | ANKQVFAVRS | GGATGVVVKG | PDDRNPISFR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| MDDRGEVKCI | KFSLENKILA | VQRTAKAVDF | CNFIPDNSQL | EYTQECKTKN | ANILGFCWTS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| STEIVFITDQ | GIEFYQVMPE | KRSLKLLKSH | NINVNWYTYC | PESAVILLST | TVLENVLQPF |
| 190 | 200 | 210 | 220 | 230 | 240 |
| HFRAGTMSKL | PKFEIELPAA | PKSTKLSLSE | RDIAMATIYG | QLYILFLRHH | SRTSNSTGAE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VVLYHLPREG | ACKKMHILKL | NRTGKFALNV | VDNLVVVHHQ | DTETSVIFDI | RLRGEFDGTV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| TFHHPVLPAR | SIQPYEIPLA | GPAAVTSQSP | VPCKLYSSSW | IVFQPDIIIS | ASQGYLWNLQ |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VKLQPIVNLL | PDKGRLMDFL | LQRKECKAVV | LSVCSQMLSE | SDRATLPVIA | TVFDKLNHEY |
| 430 | 440 | 450 | 460 | 470 | 480 |
| KKYLDADQSY | TMAVEAGQSR | SNPPLKRPVR | TQAVVDQSDV | YTQVLSPFVE | NKEMPHKFVI |
| 490 | 500 | 510 | 520 | 530 | 540 |
| AVLMEYIRSL | NQFQIPVQHY | LHELVIKTLV | QHNLFYMLHQ | FLQYHVLSDS | KPLACLLLSL |
| 550 | 560 | 570 | 580 | 590 | 600 |
| ESFYPPAHQL | SLDMLKRLST | ANDEIVEVLL | SKHQVLAALR | FIRGIGGHDN | ISARKFLDAA |
| 610 | 620 | 630 | 640 | 650 | |
| RQTDDVMLFY | TIFRFFEQRN | QRLRGNPNFT | PGEHCEEHVA | FFKQVFGEQA | LMRPTTF |