Q8UHJ6
Gene name |
ileS |
Protein name |
Isoleucine--tRNA ligase |
Names |
Isoleucyl-tRNA synthetase, IleRS |
Species |
Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens (strain C58)) |
KEGG Pathway |
atu:Atu0686 |
EC number |
6.1.1.5: Ligases forming aminoacyl-tRNA and related compounds |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8UHJ6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8UHJ6-F1 | Predicted | AlphaFoldDB |
No variants for Q8UHJ6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q8UHJ6 | |||||
No associated diseases with Q8UHJ6
4 regional properties for Q8UHJ6
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Aminoacyl-tRNA synthetase, class I, conserved site | 64 - 75 | IPR001412 |
| domain | Aminoacyl-tRNA synthetase, class Ia | 35 - 678 | IPR002300 |
| domain | Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding | 723 - 871 | IPR013155 |
| domain | Isoleucyl tRNA synthetase type 1, anticodon-binding domain | 679 - 854 | IPR033708 |
Functions
| Description | ||
|---|---|---|
| EC Number | 6.1.1.5 | Ligases forming aminoacyl-tRNA and related compounds |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| aminoacyl-tRNA editing activity | The hydrolysis of an incorrectly aminoacylated tRNA. |
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| isoleucine-tRNA ligase activity | Catalysis of the reaction: L-isoleucine + ATP + tRNA(Ile) = L-isoleucyl-tRNA(Ile) + AMP + diphosphate + 2 H(+). |
| tRNA binding | Binding to a transfer RNA. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| isoleucyl-tRNA aminoacylation | The process of coupling isoleucine to isoleucyl-tRNA, catalyzed by isoleucyl-tRNA synthetase. The isoleucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a isoleucine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSDTAEKLDY | STTLYLPQTD | FPMRAGLPQK | EPETVKRWQD | MGLYKKLRAS | AAGREKFVLH |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DGPPYANGNI | HIGHALNKIL | KDVITRSFQM | RGFDANYVPG | WDCHGLPIEW | KIEEAYRARG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KNKDEVPVNE | FRKECRDFAA | GWIKVQSEEF | KRLGIEGDFE | NPYTTMNFHA | EARIAGELLK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| IARSGQLYRG | SKPIMWSVVE | RTALAEAEVE | YHDVESDMIW | VKFPVKDAAP | ALSGVSVVIW |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TTTPWTIPGN | RAIAFSSRVE | YGLFEVESAQ | NDFGPQTGEK | LIFARKLADE | AAAKAKLTFK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| FVRDVKSEEL | AAITCAHPLA | SLGYDFPVPL | LDGDHVTDDA | GTGFVHTAPS | HGREDFDAWT |
| 370 | 380 | 390 | 400 | 410 | 420 |
| NSVRTLEARG | IDTKIPFPVD | DAGFYTEDAP | GFGPSAEGGA | ARVMDDNGKK | GDANERVIKA |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LIAANNLFAR | GRLKHSYPHS | WRSKKPVIFR | NTPQWFVYMD | KELGDGTTLR | SRSLDAIDQT |
| 490 | 500 | 510 | 520 | 530 | 540 |
| RFVPASGQNR | LRAMIEGRPD | WVLSRQRSWG | VPIAVFADEQ | GEVLVDEAVN | ARILEAFEAE |
| 550 | 560 | 570 | 580 | 590 | 600 |
| GADAWFAEGA | KERFLGNDHD | HAKWQQVMDI | LDVWFDSGCT | HTFTLEDRPD | MKWPADVYLE |
| 610 | 620 | 630 | 640 | 650 | 660 |
| GSDQHRGWFH | SSLLESCATR | GRAPYNAVVT | HGFTMDEQGR | KQSKSLGNVV | APQDVMKESG |
| 670 | 680 | 690 | 700 | 710 | 720 |
| ADILRLWVMT | TDYWEDQRLG | KAIIQTNIDA | YRKLRNTVRW | MLGTLAHDNG | EEIAYADLPE |
| 730 | 740 | 750 | 760 | 770 | 780 |
| LEKLVLHRLS | ELDKVVRDGY | DAFDFKKITR | ALIDFANVEL | SAFYFDIRKD | TLYCDAPSSL |
| 790 | 800 | 810 | 820 | 830 | 840 |
| KRRASLSVIA | KLFDCLVTWL | APMLPFTTEE | AWLSRYPDAE | SVHLAQFPEI | PAEWKNDALE |
| 850 | 860 | 870 | 880 | 890 | 900 |
| AKWEKIRKVR | TVVTGALEVE | RREKRIGSSL | EAAPVVHIAD | SDLLAALSGQ | DFAEICITSA |
| 910 | 920 | 930 | 940 | 950 | 960 |
| ITVVGDEGPA | DGFRLQEVAK | VVVEQKLAEG | VKCARSWRIT | TDVGSDPQYP | DVSARDAAAL |
| RELAALK |