Q8U4D3

PR
Gene name
asnS (PF0155)
Protein name
Asparagine--tRNA ligase
Names
Asparaginyl-tRNA synthetase, AsnRS
Species
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
KEGG Pathway
pfu:PF0155
EC number
6.1.1.22: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-40 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8U4D3

Entry ID Method Resolution Chain Position Source
AF-Q8U4D3-F1 Predicted AlphaFoldDB

No variants for Q8U4D3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8U4D3

No associated diseases with Q8U4D3

3 regional properties for Q8U4D3

Type Name Position InterPro Accession
domain Aminoacyl-tRNA synthetase, class II (D/K/N) 116 - 428 IPR004364
domain OB-fold nucleic acid binding domain, AA-tRNA synthetase-type 19 - 98 IPR004365
domain Aminoacyl-tRNA synthetase, class II 135 - 426 IPR006195

Functions

Description
EC Number 6.1.1.22 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
asparagine-tRNA ligase activity Catalysis of the reaction: L-asparagine + ATP + tRNA(Asn) = AMP + Asn-tRNA(Asn) + diphosphate + 2 H(+).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
nucleic acid binding Binding to a nucleic acid.

1 GO annotations of biological process

Name Definition
asparaginyl-tRNA aminoacylation The process of coupling asparagine to asparaginyl-tRNA, catalyzed by asparaginyl-tRNA synthetase. The asparaginyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of an asparagine-accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MIEKVYCSEV KPELEGKKVK LAGWVYSNMK VGKKIFLWIR DSTGIVQTVI AKNVVGEEVF
70 80 90 100 110 120
EKAKKLGRES SVIVEGIVKA DERAPGGAEV RVEKLEVIQA VSEFPIPENP EQASPELLLD
130 140 150 160 170 180
YRHLHIRTPK ASAIMKVKET LIMAAREWLL KDGWHEVFPP ILVTGAVEGG ATLFKLKYFD
190 200 210 220 230 240
KYAYLSQSAQ LYLEAAIFGL EKVWSLTPSF RAEKSRTRRH LTEFWHLELE AAWMDLWDIM
250 260 270 280 290 300
KVEEELVSYM VQRTLELRKK EIEMFRDDLT TLKNTEPPFP RISYDEAIDI LQSKGINVQW
310 320 330 340 350 360
GDDLGADEER VLTEEFDRPF FVYGYPKQIK AFYMKEDPND PRKVLAADML APEGYGEIIG
370 380 390 400 410 420
GSQREDDYEK LLNRILEEGM DPKDYEWYLD LRKYGSVPHS GFGLGVERLV AWVLKLDHIR
430
WASLFPRTPA RLYP