Q8U425

PR
Gene name
alaS
Protein name
Alanine--tRNA ligase
Names
Alanyl-tRNA synthetase, AlaRS
Species
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
KEGG Pathway
pfu:PF0270
EC number
6.1.1.7: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

396-538 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8U425

Entry ID Method Resolution Chain Position Source
AF-Q8U425-F1 Predicted AlphaFoldDB

No variants for Q8U425

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8U425

No associated diseases with Q8U425

4 regional properties for Q8U425

Type Name Position InterPro Accession
domain DHHA1 domain 727 - 865 IPR003156
domain Threonyl/alanyl tRNA synthetase, SAD 648 - 691 IPR012947
domain Alanyl-tRNA synthetase, class IIc, N-terminal 7 - 551 IPR018164
domain Alanyl-tRNA synthetase, class IIc, core domain 3 - 704 IPR018165

Functions

Description
EC Number 6.1.1.7 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

5 GO annotations of molecular function

Name Definition
alanine-tRNA ligase activity Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEFVMKTRMF EEEGWIRKTC KVCGKPFWTL DPDRETCGDP PCDEYQFIGK PGIPKKYTLD
70 80 90 100 110 120
EMREKFLSFF EKHEVYPHGR VKRYPVLPRW RDDVLLVGAS IMDFQPWVIS GEADPPANPL
130 140 150 160 170 180
TISQPSIRFT DIDNVGITGR HFTIFEMMAH HAFNYPGKHI YWIDETVELA FEFFTKELKM
190 200 210 220 230 240
KPEDITFKEN PWAGGGNAGP AFEVLYKGLE VATLVFMQYK KAPANADPSQ VVIIKGEKYV
250 260 270 280 290 300
PMETKVVDTG YGLERLVWMS QGTPTAYDAV LGYVIEPLKR MAGVEKIDER ILMENSRLAG
310 320 330 340 350 360
MFDIEDMGDL RYLREQVAKR VGISVEELER LIRPYELIYA IADHTKALTF MLADGVVPSN
370 380 390 400 410 420
VKAGYLARLL IRKSIRHLRE LGLEVPLAEI VAMHIKELSP TFPEFKEMED IILEMIELEE
430 440 450 460 470 480
KKYAETLRRG SDLVKREIAK LKKKGANEIP LEKLITFYES HGLTPEIVKE IAEKEGVKVH
490 500 510 520 530 540
IPDNFYSLVA KEAEKQVEEK EEEVVDFELV KDLPDTRTLY YEDPFMKEFD AKVLKVIEDW
550 560 570 580 590 600
VVLDQTAFYP EGGGQPYDTG ILVVDGEEVK VTNVQKVGKV ILHKVERPEL FKEGTIVHGR
610 620 630 640 650 660
IDWERRIQHM RHHTGTHVLM GALVRVLGKH VWQAGSQLST DWARLDITHY KRISDEEIKE
670 680 690 700 710 720
IERLANRVVM ENRRVRWEWL PRTEADEKYG FRLYQGGVVP GRIIRILNIE DWDVQACGGT
730 740 750 760 770 780
HLPSTGLIGP IKILRTERIQ DGVERIIFAC GEAAVREWQK EREIIKRTSQ ILRVPPEKLP
790 800 810 820 830 840
ETAERFFNEW KEARKEVEKL RKELAKLLVY ELESKVEKVG EIEFIGEIVE GSMDDLREAA
850 860 870 880 890 900
NKLRKENRVV VLVNKEGHFV VAVGDKLPYT AGEFAKLITS VAGGGGGGRK ELAQGKIRDI
910
EKAKEAIEKV KGSL