Q8U3K8

PR
Gene name
PF0458
Protein name
Nicotinamide-nucleotide adenylyltransferase
Names
NAD(+) diphosphorylase, NAD(+) pyrophosphorylase, NMN adenylyltransferase
Species
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
KEGG Pathway
pfu:PF0458
EC number
2.7.7.1: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

138-188 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8U3K8

Entry ID Method Resolution Chain Position Source
AF-Q8U3K8-F1 Predicted AlphaFoldDB

No variants for Q8U3K8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8U3K8

No associated diseases with Q8U3K8

1 regional properties for Q8U3K8

Type Name Position InterPro Accession
domain Cytidyltransferase-like domain 3 - 137 IPR004821

Functions

Description
EC Number 2.7.7.1 Nucleotidyltransferases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
nicotinamide-nucleotide adenylyltransferase activity Catalysis of the reaction: ATP + nicotinamide nucleotide = diphosphate + NAD+.

1 GO annotations of biological process

Name Definition
NAD biosynthetic process The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKRGLFVGRF QPVHKGHIKA LEFVFDQVDE VIIGIGSAQA SHTLKNPFTT GERMEMLIRA
70 80 90 100 110 120
LDESGLSKKK RYYLIPLPDI NFNAIWVPYV ESMVPKFEVV FTGNSLVAQL FRERGYKVVV
130 140 150 160 170 180
QPMFKKDILS ATEIRRRMIE GEPWEDLVPK SVAEYIKEIR GVERIRMLAT NLESSEKELQ
APIRIPEY