Q8U3J2

PR
Gene name
mutS2
Protein name
DNA-binding protein MutS2
Names
Species
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
KEGG Pathway
pfu:PF0474
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-141 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8U3J2

Entry ID Method Resolution Chain Position Source
AF-Q8U3J2-F1 Predicted AlphaFoldDB

No variants for Q8U3J2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8U3J2

No associated diseases with Q8U3J2

1 regional properties for Q8U3J2

Type Name Position InterPro Accession
domain DNA mismatch repair protein MutS, C-terminal 373 - 561 IPR000432

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP-dependent DNA damage sensor activity A molecule that recognises toxic DNA structures, and initiates a signalling response, driven by ATP hydrolysis.
hydrolase activity Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
mismatched DNA binding Binding to a double-stranded DNA region containing one or more mismatches.

1 GO annotations of biological process

Name Definition
mismatch repair A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKLRGDAREV YKRLLSRLES MIKLGEARTF LKKFEPTSDR EEIIKRQNYL KEGLKNVRDD
70 80 90 100 110 120
LEEYLLSIRP IRFRREFFHD RILLVSDEEV EEAEKLDLCP VTSDPSEIED YPLILSTIGY
130 140 150 160 170 180
GIEVEVKPSH IAPELYIIPL WENRDVLEAL SKVFPGGAAD KILISLKEIE EIFKKMEILE
190 200 210 220 230 240
NLDEIIVEKE KELNRKIEEK LERFKLTLSG RDLVEFMKAL RAGNLEYLFH KFSALNDEII
250 260 270 280 290 300
EEINKAEKEI SDVLGISVEI FPRDFPVEVP PEQIEALKRE LEREFKIEFY LKSRETVEKI
310 320 330 340 350 360
LPHLQKLKEE IQKAYELYFL LVVKKFTRDF VFPEIVEEGI GFIEGRNLFI ENPQPVSYFV
370 380 390 400 410 420
GKSYGNFPGV EEANIVILTG ANSGGKTSLL ELISQIVILA HMGFPVPAKK AWFTVLDEIF
430 440 450 460 470 480
FFKRKRSVYG AGAFETSLKG LVRAIKGKGK KLILIDEFES ITEPGAAAKI LAELLKIAYE
490 500 510 520 530 540
KGFFVVIVSH LGEDLKREIP FARVDGIEAK GLDENLNLIV DRQPKFGVIG RSTPELIVER
550 560
LARKGRGEEK MIMNRILKKF RK