Q8U2D5

PR
Gene name
PF0904
Protein name
N-glycosylase/DNA lyase
Names
8-oxoguanine DNA glycosylase, AGOG, DNA-(apurinic or apyrimidinic site) lyase, AP lyase
Species
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
KEGG Pathway
pfu:PF0904
EC number
4.2.99.18: Other carbon-oxygen lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

201-242 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

3 structures for Q8U2D5

Entry ID Method Resolution Chain Position Source
1XG7 X-ray 188 A A/B 2-242 PDB
4PII X-ray 217 A A 2-242 PDB
AF-Q8U2D5-F1 Predicted AlphaFoldDB

No variants for Q8U2D5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8U2D5

No associated diseases with Q8U2D5

No regional properties for Q8U2D5

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q8U2D5

Functions

Description
EC Number 4.2.99.18 Other carbon-oxygen lyases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
class I DNA-(apurinic or apyrimidinic site) endonuclease activity Catalysis of the cleavage of an AP site 3' of the baseless site by a beta-lyase mechanism, leaving an unsaturated aldehyde, termed a 3'-(4-hydroxy-5-phospho-2-pentenal) residue, and a 5'-phosphate.
oxidized base lesion DNA N-glycosylase activity Catalysis of the removal of oxidized bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site.

1 GO annotations of biological process

Name Definition
base-excision repair In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MRELVEIIKG IGIEGAKEVE EKVDRQFYAL QYLFRHQDPE MFIKLVIANS LVSYQLTGRG
70 80 90 100 110 120
EDWWWEFARY FSGREVDSIW KAYGEFLPKS KNNRRLIEAK LNRIRKVEGF LSTLTLKDLE
130 140 150 160 170 180
GYYKNMKMLW KALIKIMGSR EDSKTIVFTV KMFGYASRIA FSRFIPYPME IPIPEDLRIK
190 200 210 220 230 240
SVTSKLTQEK PTKFWMKIGQ ESGVPPLHID SLIWPLLGNA DLTPLDIELR NKLMKLTELL
GL