Q8U221

PR
Gene name
metG
Protein name
Methionine--tRNA ligase
Names
Methionyl-tRNA synthetase, MetRS
Species
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
KEGG Pathway
pfu:PF1030
EC number
6.1.1.10: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

535-604 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8U221

Entry ID Method Resolution Chain Position Source
AF-Q8U221-F1 Predicted AlphaFoldDB

No variants for Q8U221

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8U221

No associated diseases with Q8U221

7 regional properties for Q8U221

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 11 - 22 IPR001412
domain tRNA-binding domain 624 - 724 IPR002547
domain Methionyl-tRNA synthetase, beta subunit, C-terminal 600 - 724 IPR004495
domain Methionyl/Leucyl tRNA synthetase 4 - 407 IPR015413
domain Methioninyl-tRNA synthetase core domain 3 - 383 IPR033911-1
domain Methioninyl-tRNA synthetase core domain 395 - 406 IPR033911-2
domain Methionyl-tRNA synthetase, anticodon-binding domain 392 - 563 IPR041872

Functions

Description
EC Number 6.1.1.10 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
methionine-tRNA ligase activity Catalysis of the reaction: ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met).
tRNA binding Binding to a transfer RNA.

1 GO annotations of biological process

Name Definition
methionyl-tRNA aminoacylation The process of coupling methionine to methionyl-tRNA, catalyzed by methionyl-tRNA synthetase. The methionyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a methionine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MVRYMVTAAL PYANGPIHAG HLAGAYLPAD IFVRYLRLKG EDVVFICGTD EHGTPISFRA
70 80 90 100 110 120
LNEKRSPREI VDEFHEHIKT AFQRVKISFD YFGRTELPVH YRLSQEFFLK ALENGYLVKK
130 140 150 160 170 180
VTKQAYCEHD KRFLPDRFVI GTCPYCGAEN QRGDQCEVCG RPLTPEILIE PRCAFCKNPI
190 200 210 220 230 240
TFRESTHYYI KMQEFEEKLK EWIKEKDWKP NVKNMVLGWI EEGLEERAIT RDLDWGIPVP
250 260 270 280 290 300
LDEEDMKNKV LYVWFEAPIG YISLTIEYFK RIGKPNEWKK YWLNLDGQTR VIHFIGKDNI
310 320 330 340 350 360
PFHAIFWPAF LMAYGKYKDE EVEAEWNLPY DIPANEYLTL EGKKFSTSRN WAIWIHEFLD
370 380 390 400 410 420
VFPADYLRYY LTSIMPETRD SDFSFAEFKT KINEELVNVL GNFVYRALTF VNRYFDGIVP
430 440 450 460 470 480
ERGELDELDR QALEEIEKTF EEVGKLIREY RFKDALKKVM NLAGFGNRYF DYKEPWKTIK
490 500 510 520 530 540
EDKTRTGTTI NISLQIVKAL GILLEPFLPD ASEKIWHFLN LEEVKTWRFT ELPAGHKVRK
550 560 570 580 590 600
PEILFKKASD DQIIYFILNY MGRNNPDAAR ELLEKYYKLE DVEKVAIEKF GEEDGRFMLK
610 620 630 640 650 660
KIFKEKYKGE KKGEQKMQYV SFEEFSKIDL RIGKIVEVQD HPNADKLYVV KVDLGGEIRT
670 680 690 700 710 720
LVAGLKKYYK PEELLNRYVV IVANLEPKKL RGVESQGMLL AADDGEKVAL LMPDKEVKLG
AKVR