Q8U1R8

PR
Gene name
infB (PF1137)
Protein name
Probable translation initiation factor IF-2
Names
Species
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
KEGG Pathway
pfu:PF1137
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

273-352 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8U1R8

Entry ID Method Resolution Chain Position Source
AF-Q8U1R8-F1 Predicted AlphaFoldDB

No variants for Q8U1R8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8U1R8

No associated diseases with Q8U1R8

3 regional properties for Q8U1R8

Type Name Position InterPro Accession
conserved_site Translation initiation factor 3, conserved site 66 - 79 IPR019813
domain Translation initiation factor 3, N-terminal 15 - 84 IPR019814
domain Translation initiation factor 3, C-terminal 91 - 177 IPR019815

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

4 GO annotations of molecular function

Name Definition
endonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks.
GTP binding Binding to GTP, guanosine triphosphate.
GTPase activity Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.
translation initiation factor activity Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.

2 GO annotations of biological process

Name Definition
intein-mediated protein splicing The removal of an internal amino acid sequence (an intein) from a protein during protein maturation; the excision of inteins is precise and the N- and C-terminal exteins are joined by a normal peptide bond. Protein splicing involves 4 nucleophilic displacements by the 3 conserved splice junction residues.
intron homing Lateral transfer of an intron to a homologous allele that lacks the intron, mediated by a site-specific endonuclease encoded within the mobile intron.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKKIRQPIIA VLGHVDHGKC LLPEEKVVLP EIGLVTLREL FELANEVVVK DEEKEVRKLG
70 80 90 100 110 120
KMLTGVDERG NVKLLNALYV WRVAHKGEMI RVKVNGWYSV TVTPEHPFLT NRGWVKAGEL
130 140 150 160 170 180
KEGDYIAIPR RVYGNEDLMK FSKIAKELGI KGDEKEFYLA GASLDIPIKV LFLAPSKLVS
190 200 210 220 230 240
AFLRGYFDAK GVVRENYIEV PLFEDLPLLL LRFGIVSRIE KSTLKISGKR NLELFRKHVG
250 260 270 280 290 300
FTDSEKAKAL DELISKAKES ERYPILEELR RLGLLFGFTR NELRIEENPT YEVLMEILER
310 320 330 340 350 360
IERGSPNLAE KIAVLEGRIK EENYLRILEE EGLIENGKLT ELGKELLEVW RNREFDSKDV
370 380 390 400 410 420
DYVRNIVENL VFLPVEKVER IEYEGYVYDV TTETHNFVAN GILVHNTTLL DRIRKTNVAA
430 440 450 460 470 480
KEAGGITQHI GATEVPIDVV KEIAGPLIKL WKAEIKLPGL LFIDTPGHEA FTSLRARGGS
490 500 510 520 530 540
LADLAVLVVD INEGFQPQTI ESIEILRRYK TPFVVAANKI DRIKGWVIQE DEPFLLNSKR
550 560 570 580 590 600
QDQRAIQELE TKLWELIGKF YEFGFQANRF DRVQNFTREL AIVPISAKYG IGIAELLVLI
610 620 630 640 650 660
AGLSQKYLEE RLKIEVEGPA RGTILEVREE PGLGHTIDVI IYEGTLHKDD TIVVGGKDKA
670 680 690 700 710 720
IVTKVRALLK PKPLDEIRDP RFRFDYVDEV TAAAGVKIAA PGLEEALAGS PVIAAPTPEA
730 740 750 760 770 780
VEKAKEEIMR QIQSVVISTD KMGVIIKADT LGSLEALSKE LQEKGIPIRK ADVGNISKTD
790 800 810 820 830 840
VMEALSVREE DPKYGVIIGF NVKVNEDAQE IAKAKGVPIF VGNIIYKLIE DYEAWVKEEE
850 860 870 880 890 900
EKKKRELLAK VTFPGVIRLY PDERYVFRRS NPAIVGIEVI EGRIKPGVTL IKQNGQKVGT
910 920 930 940 950 960
IKSIKSRDEF LQEAKKGQAV AVAIEGAIVG RHIHPGETLY VDISRDDAIT LLKYLRDVLE
970 980
DSDIKALKII AQIKAKEDPF WRAI