Q8U1K2

PR
Gene name
serS
Protein name
Serine--tRNA ligase
Names
Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase
Species
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
KEGG Pathway
pfu:PF1204
EC number
6.1.1.11: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

21-121 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8U1K2

Entry ID Method Resolution Chain Position Source
AF-Q8U1K2-F1 Predicted AlphaFoldDB

No variants for Q8U1K2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8U1K2

No associated diseases with Q8U1K2

4 regional properties for Q8U1K2

Type Name Position InterPro Accession
domain Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) 230 - 411 IPR002314
domain Aminoacyl-tRNA synthetase, class II 173 - 421 IPR006195
domain Serine-tRNA synthetase, type1, N-terminal 1 - 109 IPR015866
domain Serine-tRNA ligase catalytic core domain 121 - 428 IPR033729

Functions

Description
EC Number 6.1.1.11 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
serine-tRNA ligase activity Catalysis of the reaction: ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser).

3 GO annotations of biological process

Name Definition
selenocysteine biosynthetic process The chemical reactions and pathways resulting in the formation of selenocysteine, an essential component of glutathione peroxidase and some other proteins.
selenocysteinyl-tRNA(Sec) biosynthetic process The chemical reactions and pathways resulting in the formation of selenocysteinyl-tRNA(Sec). This process occurs through the following steps: a unique serine-tRNA with a UGA recognizing anticodon is first aminoacylated with serine; this is then phosphorylated by phosphoseryl-tRNA
seryl-tRNA aminoacylation The process of coupling serine to seryl-tRNA, catalyzed by seryl-tRNA synthetase. The seryl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a serine-accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLDINLIRNN PELVKNDLKK RGELDKIAWI DEILRLDEEW RKKLKEINRL RHERNKIAIE
70 80 90 100 110 120
IGKRKKAGEP VEDLLAKSKE IVKRIEELEK EVEELRKRID YYLWRLPNIT HPSVPVGKDE
130 140 150 160 170 180
NDNVPIRFWG KAKVWKGHLE SFLEQSQGKM EYEVLEWRPK LHVDLLEILG GADFARAAKV
190 200 210 220 230 240
SGSRFYYLLN EIVILDLALI RFALDRLIEK GFTPVIPPYM VRRFVEEGST TFEDFEDVIY
250 260 270 280 290 300
KVEGEDLYLI PTAEHPLAGM HANEILDGKD LPLLYVAFSP CFRKEAGTAG KDTKGIFRVH
310 320 330 340 350 360
QFHKVEQFVY SRPEESWEWH ERLVRNAEEL FQELEIPYRV VNICTGDLGY VAAKKYDIEA
370 380 390 400 410 420
WMPGQGRFRE VVSASNCTDW QARRLNIRFR DRTDEKPRYV HTLNSTAIAT SRAIVAILEN
430 440 450
HQQEDGTVKI PRALWKYTGF KEIVPVEKKE GCCKA