Q8U176

PR
Gene name
thrS
Protein name
Threonine--tRNA ligase
Names
Threonyl-tRNA synthetase, ThrRS
Species
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
KEGG Pathway
pfu:PF1351
EC number
6.1.1.3: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-64 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8U176

Entry ID Method Resolution Chain Position Source
AF-Q8U176-F1 Predicted AlphaFoldDB

No variants for Q8U176

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8U176

No associated diseases with Q8U176

6 regional properties for Q8U176

Type Name Position InterPro Accession
domain Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) 289 - 494 IPR002314
domain Anticodon-binding 507 - 597 IPR004154
domain Aminoacyl-tRNA synthetase, class II 235 - 500 IPR006195
domain Threonyl/alanyl tRNA synthetase, SAD 136 - 185 IPR012947
domain Threonine-tRNA ligase catalytic core domain 209 - 505 IPR033728
domain Threonine-tRNA ligase, class IIa, anticodon-binding domain 505 - 596 IPR047246

Functions

Description
EC Number 6.1.1.3 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

5 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
threonine-tRNA ligase activity Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr).
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
threonyl-tRNA aminoacylation The process of coupling threonine to threonyl-tRNA, catalyzed by threonyl-tRNA synthetase. The threonyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a threonine-accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MRMLLIHSDY IEYEVKDKAI KNPEPISEEE KKGRMDEVLV AFISVEKVDE KNPDEVVEKA
70 80 90 100 110 120
INEIIEVAKQ VKAENLFVYP FAHLSSELAK PSVAQEVLRR IYEGLKERGY NVGKAPFGYY
130 140 150 160 170 180
KAFRISCKGH PLAELSRTIV PEEAKVEEVP EALKKEETEL VSYWYILTPE GELVEVDKFD
190 200 210 220 230 240
FTGHENLRKF ANYEIAKSRI ADKEPPHVRL MLEHELVDYE PGSDPGNLRY YPKGRLIKSL
250 260 270 280 290 300
LEQYVSEKVI EYGAMEVETP IMYDFEHPAL EKYLNRFPAR QYIVLSGDKR YFLRFAACFG
310 320 330 340 350 360
QFMISKDATI SYRNLPLRMY ELTRYSFRRE KRGELSGLRR LRAFTMPDMH TLAKDIEQAK
370 380 390 400 410 420
DEFKKQFKLS MEVLGGVGLT PDDYEVAIRF TEDFWNEHKD FIIELVKLIG KPVLIEMWKQ
430 440 450 460 470 480
RFFYFILKFE FNFVDNLDKA AALSTVQIDV ENAERFGITY YDENGEEKYP LILHCSPSGA
490 500 510 520 530 540
IERVMYAILE KQAKLMQEGK KPMFPLWLSP IQVRVIPVSK EYLDYALYVA GKIEGARIRV
550 560 570 580 590 600
DVDDEDERLS KKIRRAEKEW IPYIVVVGEK EKETGTITVR RREDGKQYET RIEELIKEIK
610 620
QKTEGFPYKP RPLPLLLSQR PKFRG