Q8U070

PR
Gene name
srp54
Protein name
Signal recognition particle 54 kDa protein
Names
SRP54
Species
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
KEGG Pathway
pfu:PF1731
EC number
3.6.5.4: Acting on GTP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-50 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for Q8U070

Entry ID Method Resolution Chain Position Source
3DM5 X-ray 251 A A/B 1-443 PDB
AF-Q8U070-F1 Predicted AlphaFoldDB

No variants for Q8U070

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8U070

No associated diseases with Q8U070

4 regional properties for Q8U070

Type Name Position InterPro Accession
domain Signal recognition particle, SRP54 subunit, GTPase domain 100 - 295 IPR000897
domain AAA+ ATPase domain 99 - 276 IPR003593
domain Signal recognition particle, SRP54 subunit, M-domain 327 - 425 IPR004125
domain Signal recognition particle SRP54, helical bundle 2 - 87 IPR013822

Functions

Description
EC Number 3.6.5.4 Acting on GTP; involved in cellular and subcellular movement
Subcellular Localization
  • Cytoplasm
  • The SRP-RNC complex is targeted to the cytoplasmic membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
signal recognition particle A complex of protein and RNA which facilitates translocation of proteins across membranes.

3 GO annotations of molecular function

Name Definition
7S RNA binding Binding to a 7S RNA, the RNA component of the signal recognition particle (SRP).
GTP binding Binding to GTP, guanosine triphosphate.
GTPase activity Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.

1 GO annotations of biological process

Name Definition
SRP-dependent cotranslational protein targeting to membrane The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MVLDNLGKAL ANTLKKIARA SSVDEALIKE LVRDIQRALI QADVNVRLVL QLTREIQRRA
70 80 90 100 110 120
LEEKPPAGIS KKEHIIKIVY EELTKFLGTE AKPIEIKEKP TILLMVGIQG SGKTTTVAKL
130 140 150 160 170 180
ARYFQKRGYK VGVVCSDTWR PGAYHQLRQL LDRYHIEVFG NPQEKDAIKL AKEGVDYFKS
190 200 210 220 230 240
KGVDIIIVDT AGRHKEDKAL IEEMKQISNV IHPHEVILVI DGTIGQQAYN QALAFKEATP
250 260 270 280 290 300
IGSIIVTKLD GSAKGGGALS AVAATGAPIK FIGTGEKIDD IEPFDPPRFV SRLLGLGDIQ
310 320 330 340 350 360
GLLEKFKELE KEVEIKEEDI ERFLRGKFTL KDMYAQLEAM RKMGPLKQIL RMIPGLGYSL
370 380 390 400 410 420
PDDVISIGEE RLKKFKVIMD SMTEEELLNP EIINYSRIKR IARGSGTSTK DVKELLDQYR
430 440
QMKKLFKSMN KRQLSRLARR FGM