Q8TZW4
Gene name |
PF1861 |
Protein name |
Lysyl aminopeptidase |
Names |
|
Species |
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) |
KEGG Pathway |
pfu:PF1861 |
EC number |
3.4.11.15: Aminopeptidases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for Q8TZW4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 4X8I | X-ray | 250 A | A/B/C | 1-346 | PDB |
| AF-Q8TZW4-F1 | Predicted | AlphaFoldDB |
No variants for Q8TZW4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q8TZW4 | |||||
No associated diseases with Q8TZW4
No regional properties for Q8TZW4
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q8TZW4 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 3.4.11.15 | Aminopeptidases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| aminopeptidase activity | Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain. |
| metal ion binding | Binding to a metal ion. |
| metallopeptidase activity | Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| proteolysis | The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVDWELMKKI | IESPGVSGYE | HLGIRDLVVD | ILKDVADEVK | IDKLGNVIAH | FKGSAPKVMV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| AAHMDKIGLM | VNHIDKDGYL | RVVPIGGVLP | ETLIAQKIRF | FTEKGERYGV | VGVLPPHLRR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EAKDQGGKID | WDSIIVDVGA | SSREEAEEMG | FRIGTIGEFA | PNFTRLSEHR | FATPYLDDRI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| CLYAMIEAAR | QLGEHEADIY | IVASVQEEIG | LRGARVASFA | IDPEVGIAMD | VTFAKQPNDK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GKIVPELGKG | PVMDVGPNIN | PKLRQFADEV | AKKYEIPLQV | EPSPRPTGTD | ANVMQINREG |
| 310 | 320 | 330 | 340 | ||
| VATAVLSIPI | RYMHSQVELA | DARDVDNTIK | LAKALLEELK | PMDFTP |