Q8TZC5
Gene name |
rfcL |
Protein name |
Replication factor C large subunit |
Names |
RFC large subunit, Clamp loader large subunit |
Species |
Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938) |
KEGG Pathway |
mka:MK0005 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8TZC5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8TZC5-F1 | Predicted | AlphaFoldDB |
No variants for Q8TZC5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q8TZC5 | |||||
No associated diseases with Q8TZC5
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| DNA clamp loader activity | Facilitating the opening of the ring structure of the PCNA complex, or any of the related sliding clamp complexes, and their closing around the DNA duplex, driven by ATP hydrolysis. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA replication | The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVPWVEKYRP | RSLKELVNQD | EAKKELAAWA | NEWARGSIPE | PRAVLLHGPP | GTGKTSAAYA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LAHDFGWDVI | ELNASDKRTR | NVIEKIVGGA | STSRSLLRMT | REAGGDYEHV | EGHSDRVLVL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VDEVDGIDPR | EDRGGVTALT | RAVRQARNPM | VLVANDPWVL | PKSLRDAVRM | IEFRRLRVND |
| 190 | 200 | 210 | 220 | 230 | 240 |
| IVEALRRICE | REGIEYEEVA | LRRIAKRARG | DLRAAINDLE | ALARPTGRVT | SDDVEALGWR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DKEITIFEAL | GRIFNKPPRQ | ARRALWNLDE | DPDDVILWIA | QNIPRAYRDP | EEIARAYDYL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SKADVFSSRA | IETGDWRFKY | VYATDLMTSG | VAAARKGKPP | GFVRFQPPKI | LRKLGTTRKE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| REVRNSIAKK | IAERMHVSTR | RAKMDVISVL | EIAFRKVADN | PTDRGLEILG | GIAGYLELSK |
| 430 | 440 | 450 | 460 | 470 | 480 |
| REIGFLCGDP | QVAQRVYQRA | LRVREKLRKI | RRERVKGAME | SMLERKREES | EVEEEAKEIE |
| 490 | 500 | ||||
| EAVEKAEEEE | EREEKKKEGG | GEQRTLDAFF |